Institute of Agro-Products Processing Science and Technology, Chinese Academy of Agricultural Sciences/Key Laboratory of Agro-Products Processing, Ministry of Agriculture, Beijing 100193, China.
Institute of Food and Nutrition Development, Ministry of Agriculture, 12 Zhongguancun South Street, Haidian District, Beijing 100081, China.
Carbohydr Polym. 2014 Nov 4;112:1-5. doi: 10.1016/j.carbpol.2014.05.061. Epub 2014 Jun 2.
The aim of the present study is to investigate the effects of dietary wheat bran arabinoxylans (AXs) on cholesterol metabolism in hypercholesterolemic hamsters. The hamsters were divided into 3 groups and fed the experimental diets containing AXs or oat β-glucan at a dose of 5 g/kg for 30 days. As the results, the AXs lowered plasma total cholesterol and LDL-cholesterol concentrations, and increased excretions of total lipids, cholesterol and bile acids, as well as oat β-glucan. The AXs reduced the activity of 3-hydroxy-3-methyl glutaryl-coenzyme A (HMG-CoA) reductase, and increased the activity of cholesterol 7-α hydroxylase (CYP7A1) in liver. Moreover, the AXs increased propionate and the total short-chain fatty acids (SCFAs) concentrations. These results indicated that dietary AXs reduced the plasma total cholesterol and LDL-cholesterol concentrations by promoting the excretion of fecal lipids, regulating the activities of HMG-CoA reductase and CYP7A1, and increasing colonic SCFAs in hamsters.
本研究旨在探讨日粮小麦麸阿拉伯木聚糖（AXs）对高胆固醇血症仓鼠胆固醇代谢的影响。将仓鼠分为 3 组，分别饲喂含 AXs 或燕麦β-葡聚糖的实验日粮，剂量为 5 g/kg，持续 30 天。结果表明，AXs 降低了血浆总胆固醇和 LDL 胆固醇浓度，增加了总脂质、胆固醇和胆汁酸的排泄，以及燕麦β-葡聚糖。AXs 降低了 3-羟-3-甲基戊二酰辅酶 A（HMG-CoA）还原酶的活性，增加了肝脏中胆固醇 7-α羟化酶（CYP7A1）的活性。此外，AXs 增加了丙酸和总短链脂肪酸（SCFAs）的浓度。这些结果表明，日粮 AXs 通过促进粪便脂质的排泄、调节 HMG-CoA 还原酶和 CYP7A1 的活性以及增加结肠 SCFAs，降低了仓鼠血浆总胆固醇和 LDL 胆固醇浓度。
