小毛壳菌 2.6 来源的 2-取代（1-3）-β-D-葡聚糖对人巨噬细胞和髓样细胞的免疫调节作用。
Immunomodulation of human macrophages and myeloid cells by 2-substituted (1-3)-β-D-glucan from P. parvulus 2.6.
机构信息
Department of Molecular Microbiology and Infection Biology, Centro de Investigaciones Biológicas, Consejo Superior de Investigaciones Científicas, Ramiro de Maeztu 9, 28040 Madrid, Spain.
出版信息
Carbohydr Polym. 2014 Nov 4;112:109-13. doi: 10.1016/j.carbpol.2014.05.073. Epub 2014 Jun 4.
β-glucans produced by eukaryotic cells and by microorganisms are known to modulate immune responses by affecting macrophage activation. Here, we have investigated the effect of purified 2-substituted (1-3)-β-D-glucan, produced by either Pediococcus parvulus 2.6 or Lactococcus lactis NZ9000[pNGTF], on the effector functions of human PMA-differentiated THP-1 cells and M1 pro-inflammatory monocyte-derived macrophages. The results reveal that this kind of β-D-glucan activates macrophages and has an anti-inflammatory effect.
真核细胞和微生物产生的β-葡聚糖已知通过影响巨噬细胞的激活来调节免疫反应。在这里，我们研究了由肠膜明串珠菌 2.6 或乳酸乳球菌 NZ9000[pNGTF]产生的经纯化的 2-取代（1-3）-β-D-葡聚糖对人 PMA 分化的 THP-1 细胞和 M1 促炎单核细胞来源的巨噬细胞的效应功能的影响。结果表明，这种β-D-葡聚糖激活巨噬细胞并具有抗炎作用。
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