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循环肿瘤细胞的检测

Detection of circulating tumor cells.

作者信息

de Wit Sanne, van Dalum Guus, Terstappen Leon W M M

机构信息

Department of Medical Cell BioPhysics, Faculty of Science and Technology, MIRA Institute for Biomedical Technology and Technical Medicine, University of Twente, Carre, Room C4437, Hallenweg 23, 7522 NH Enschede, The Netherlands.

出版信息

Scientifica (Cairo). 2014;2014:819362. doi: 10.1155/2014/819362. Epub 2014 Jul 15.

DOI:10.1155/2014/819362
PMID:25133014
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4124199/
Abstract

The increasing number of treatment options for patients with metastatic carcinomas has created an accompanying need for methods to determine if the tumor will be responsive to the intended therapy and to monitor its effectiveness. Ideally, these methods would be noninvasive and provide quantitative real-time analysis of tumor activity in a variety of carcinomas. Assessment of circulating tumor cells shed into the blood during metastasis may satisfy this need. Here we review the CellSearch technology used for the detection of circulating tumor cells and discuss potential future directions for improvements.

摘要

转移性癌患者的治疗选择日益增多，随之而来的是需要有方法来确定肿瘤对预期治疗是否有反应，并监测其疗效。理想情况下，这些方法应是非侵入性的，且能对多种癌的肿瘤活性进行定量实时分析。评估转移过程中释放入血的循环肿瘤细胞或许能满足这一需求。在此，我们回顾用于检测循环肿瘤细胞的CellSearch技术，并讨论未来潜在的改进方向。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4b2f/4124199/c43fb5aefb9d/SCIENTIFICA2014-819362.007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4b2f/4124199/2aa93be70501/SCIENTIFICA2014-819362.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4b2f/4124199/5e35e258e2cc/SCIENTIFICA2014-819362.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4b2f/4124199/ea1b5b8bce0d/SCIENTIFICA2014-819362.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4b2f/4124199/a30bbdb8b163/SCIENTIFICA2014-819362.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4b2f/4124199/ee86f1979125/SCIENTIFICA2014-819362.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4b2f/4124199/2f0a5461044b/SCIENTIFICA2014-819362.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4b2f/4124199/c43fb5aefb9d/SCIENTIFICA2014-819362.007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4b2f/4124199/2aa93be70501/SCIENTIFICA2014-819362.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4b2f/4124199/5e35e258e2cc/SCIENTIFICA2014-819362.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4b2f/4124199/ea1b5b8bce0d/SCIENTIFICA2014-819362.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4b2f/4124199/a30bbdb8b163/SCIENTIFICA2014-819362.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4b2f/4124199/ee86f1979125/SCIENTIFICA2014-819362.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4b2f/4124199/2f0a5461044b/SCIENTIFICA2014-819362.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4b2f/4124199/c43fb5aefb9d/SCIENTIFICA2014-819362.007.jpg

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