人类癌症的小鼠模型。

Mouse models of human cancer.

机构信息

Division of Vascular Oncology and Metastasis, German Cancer Research Center Heidelberg (DKFZ-ZMBH Alliance), Heidelberg, Germany. Department of Vascular Biology and Tumor Angiogenesis (CBTM), Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.

Max-Delbrück-Center for Molecular Medicine (MDC), Berlin, Germany. Experimental and Clinical Research Center, Charité University Medicine, Berlin, Germany. German Consortium for Translational Cancer Research (DKTK), Heidelberg, Germany.

出版信息

Cancer Res. 2014 Sep 1;74(17):4671-5. doi: 10.1158/0008-5472.CAN-14-1424. Epub 2014 Aug 18.

DOI:10.1158/0008-5472.CAN-14-1424

PMID:25136075

Abstract

The Helmholtz Alliance Preclinical Comprehensive Cancer Center (PCCC; www.helmholtz-pccc.de) hosted the "1st International Kloster Seeon Meeting on Mouse Models of Human Cancer" in the Seeon monastery (Germany) from March 8 to 11, 2014. The meeting focused on the development and application of novel mouse models in tumor research and high-throughput technologies to overcome one of the most critical bottlenecks in translational bench-to-bedside tumor biology research. Moreover, the participants discussed basic molecular mechanisms underlying tumor initiation, progression, metastasis, and therapy resistance, which are the prerequisite for the development of novel treatment strategies and clinical applications in cancer therapy.

摘要

德国施泰因贝格的赫尔姆霍茨综合癌症研究中心（PCCC；www.helmholtz-pccc.de）于 2014 年 3 月 8 日至 11 日在当地的塞森修道院举办了第一届“人类肿瘤的施泰因贝格塞森小鼠模型国际研讨会”。会议重点关注了新型小鼠肿瘤模型的开发和应用，以及克服转化床旁肿瘤生物学研究中最关键瓶颈之一的高通量技术。此外，与会者还讨论了肿瘤发生、进展、转移和治疗抵抗的基本分子机制，这是开发新型治疗策略和癌症治疗临床应用的前提。