Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA.
Curr Opin Immunol. 2010 Feb;22(1):34-40. doi: 10.1016/j.coi.2010.01.004. Epub 2010 Feb 9.
Not only does the innate immune system represent the first line of defense against invading pathogens, but it is also responsible for instructing appropriate adaptive immune responses. Pattern recognition receptors (PRR) detect the presence of invading pathogens and are paramount in innate instruction of the adaptive immune response. A diverse class of PRRs, the NOD-like Receptors (NLR), has recently been implicated in the regulation of processes ranging from anti-tumor immunity to the adjuvant action of aluminum hydroxide. In this review we will highlight many of the recent findings in the NLR field with a particular focus on NLR influence of adaptive immune responses.
先天免疫系统不仅是抵御入侵病原体的第一道防线，还负责指导适当的适应性免疫反应。模式识别受体 (PRR) 可检测到入侵病原体的存在，在先天指导适应性免疫反应中至关重要。最近，一类多样化的 PRR，即 NOD 样受体 (NLR)，已被牵连到从抗肿瘤免疫到氢氧化铝佐剂作用等各种过程的调节中。在这篇综述中，我们将重点介绍 NLR 领域的许多最新发现，特别关注 NLR 对适应性免疫反应的影响。
