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载脂蛋白 TG/HDL-C 比值可作为中国非肥胖女性胰岛素抵抗的替代指标。

The TG/HDL-C Ratio Might Be a Surrogate for Insulin Resistance in Chinese Nonobese Women.

机构信息

Department of Cardiovascular Medicine, West China Hospital, Sichuan University, Chengdu 610041, China.

出版信息

Int J Endocrinol. 2014;2014:105168. doi: 10.1155/2014/105168. Epub 2014 Jul 21.

Abstract

Obejective. To examine the discriminatory power of triglyceride (TG) and triglyceride to high-density lipoprotein cholesterol ratio (TG/HDL-C) for insulin resistance (IR) in a normoglycaemic Chinese population. Methods. The data were collected from 711 individuals. The normoglycaemic individuals were eventually included in the study (n = 533, age: 62.8 ± 6.6 years, male: 56.8%), who were with a fasting plasma glucose < 6.1 mmol/L and without a history of diabetes. IR was defined as the upper quintile (≥1.6) of homeostasis model assessment of IR. Area under the receiver operating characteristic curve (AROC) was used to examine the discriminatory power. Results. The discriminatory power of TG/HDL-C for IR was acceptable in women with a BMI < 24 kg/m(2) or waist circumference < 80 cm (AROCs: 0.718 and 0.713, resp.); however, the discriminatory power was not acceptable in the obese women. TG/HDL-C was not an acceptable marker of IR in men. The discriminatory power of TG for IR was not acceptable in both men and women. Conclusions. The discriminatory power of TG/HDL-C for IR differs by gender and obesity index in the normoglycaemic Chinese population, and TG/HDL-C could discriminate IR in the nonobese and normoglycaemic women.

摘要

目的。探讨甘油三酯(TG)和甘油三酯与高密度脂蛋白胆固醇比值(TG/HDL-C)在正常血糖的中国人中对胰岛素抵抗(IR)的鉴别能力。

方法。该数据来自 711 个人。最终将正常血糖的个体纳入研究(n=533,年龄:62.8±6.6 岁,男性:56.8%),空腹血浆葡萄糖<6.1mmol/L,无糖尿病史。IR 定义为稳态模型评估的 IR 的上五分位数(≥1.6)。使用接收者操作特征曲线(AROC)下面积来评估鉴别能力。

结果。在 BMI<24kg/m(2)或腰围<80cm 的女性中,TG/HDL-C 对 IR 的鉴别能力尚可(AROCs:0.718 和 0.713);然而,在肥胖女性中,该鉴别能力不可靠。在男性中,TG/HDL-C 不是 IR 的可靠标志物。在男性和女性中,TG 对 IR 的鉴别能力均不可靠。

结论。在正常血糖的中国人中,TG/HDL-C 对 IR 的鉴别能力因性别和肥胖指数而异,在非肥胖和正常血糖的女性中,TG/HDL-C 可鉴别 IR。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8af8/4130201/d87ddd836d49/IJE2014-105168.001.jpg

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