Khoury Maroun, Alcayaga-Miranda Francisca, Illanes Sebastián E, Figueroa Fernando E
Laboratory of Nano-Regenerative Medicine, Faculty of Medicine, Universidad de Los Andes , Santiago , Chile ; Cells for Cells , Santiago , Chile ; REGENERO, Consortium in Tissue Engineering , Santiago , Chile.
Laboratory of Nano-Regenerative Medicine, Faculty of Medicine, Universidad de Los Andes , Santiago , Chile ; Cells for Cells , Santiago , Chile.
Front Immunol. 2014 May 19;5:205. doi: 10.3389/fimmu.2014.00205. eCollection 2014.
Menstrual-derived stem cells (MenSCs) are a new source of mesenchymal stem cells isolated from the menstrual fluid. Currently, there is a growing interest in their clinical potential due to fact that they are multipotent, highly proliferative, and easy to obtain in a non-invasive manner. Sampling can be repeated periodically in a simplified and reproducible manner devoid of complications that no existing cell source can match. MenSCs are also free of ethical dilemmas, and display novel properties with regard to presently known adult derived stem cells. This review details their distinctive biological properties regarding immunophenotype and function, proliferation rate, differentiation potential, and paracrine effects mediated by secreted factors. Their possible role in antenatal diagnosis is also discussed. While more insight on their immunomodulatory and diagnostic properties is needed, the impact of clinical and epidemiological factors, such as age, use of contraceptives, or hormonal status still requires further investigations to properly assess their current and future use in clinical application and diagnosis.
月经来源的干细胞（MenSCs）是从月经液中分离出来的一种新的间充质干细胞来源。目前，由于它们具有多能性、高增殖性且易于以非侵入性方式获取，人们对其临床潜力的兴趣与日俱增。采样可以以简化且可重复的方式定期进行，没有并发症，这是现有任何细胞来源都无法比拟的。MenSCs也不存在伦理困境，并且相对于目前已知的成人来源干细胞具有新的特性。本综述详细介绍了它们在免疫表型和功能、增殖率、分化潜能以及由分泌因子介导的旁分泌作用方面的独特生物学特性。还讨论了它们在产前诊断中的可能作用。虽然需要对其免疫调节和诊断特性有更多了解，但临床和流行病学因素，如年龄、避孕药的使用或激素状态的影响仍需要进一步研究，以正确评估它们在临床应用和诊断中的当前及未来用途。
