From the Institute for Cardiovascular Prevention, Ludwig-Maximilians-University Munich, Munich, Germany (Y.D., M.D., O.S., C.W.); Department of Pathology, Academic Medical Center, Amsterdam University, Amsterdam, The Netherlands (M.D., O.S.); and German Centre for Cardiovascular Research (DZHK), Partner Site Munich Heart Alliance, Munich, Germany (O.S., C.W.).
Arterioscler Thromb Vasc Biol. 2015 Feb;35(2):288-95. doi: 10.1161/ATVBAHA.114.303564. Epub 2014 Aug 21.
Infiltration of leukocyte subsets is a driving force of atherosclerotic lesion growth, and during the past decade, neutrophils have received growing attention in chronic inflammatory processes, such as atherosclerosis. Equipped with various ready to be released mediators, evolved to fight invading pathogens, neutrophils may also hold key functions in affecting sterile inflammation, such as in atherosclerosis. Many of their secretion products might instruct or activate other immune cells (particularly monocytes) to, for example, enter atherosclerotic lesions or release proinflammatory mediators. Despite the emerging evidence for the mechanistic contribution of neutrophils to early atherosclerosis in mice, their role in human atherogenesis, atheroprogression, and atherosclerotic plaque destabilization is still poorly understood. This brief review will summarize latest findings on the role of neutrophils in atherosclerosis and will pay special attention to studies describing a translation approach by combining measurements in mouse and human.
白细胞亚群的浸润是动脉粥样硬化病变生长的驱动力，在过去十年中，中性粒细胞在慢性炎症过程中，如动脉粥样硬化，受到越来越多的关注。中性粒细胞配备了各种准备好释放的介质，这些介质是为了对抗入侵的病原体而进化的，它们在影响非感染性炎症（如动脉粥样硬化）方面也可能具有关键功能。它们的许多分泌产物可能会指示或激活其他免疫细胞（特别是单核细胞）进入动脉粥样硬化病变或释放促炎介质。尽管有越来越多的证据表明中性粒细胞在小鼠早期动脉粥样硬化中的作用，但它们在人类动脉粥样硬化形成、动脉粥样硬化进展和动脉粥样硬化斑块不稳定中的作用仍知之甚少。这篇简短的综述将总结中性粒细胞在动脉粥样硬化中的作用的最新发现，并特别关注描述在小鼠和人类中结合测量来进行转化研究的研究。
