Hartwig H, Silvestre Roig C, Daemen M, Lutgens E, Soehnlein O
Helene Hartwig, AMC - Department of Pathology, Meibergdreef 15,1105 AZ Amsterdam, NL, E-mail:
Hamostaseologie. 2015;35(2):121-7. doi: 10.5482/HAMO-14-09-0040. Epub 2014 Nov 11.
Atherosclerosis is a chronic inflammation of the arterial wall and the continuous infiltration of leukocytes into the plaque enhances the progression of the lesion. Because of the scarce detection of neutrophils in atherosclerotic plaques compared to other immune cells, their contribution was largely neglected. However, in the last years studies have accumulated pointing towards the contribution of neutrophils to atherogenesis. In addition, studies are emerging implying a role for neutrophils in advanced atherosclerosis and/or plaque destabilization. Thus, this brief review delivers an overview of the role of neutrophils during early and late stage atherosclerosis.
动脉粥样硬化是动脉壁的慢性炎症，白细胞持续浸润到斑块中会加速病变进展。与其他免疫细胞相比，由于在动脉粥样硬化斑块中很少检测到中性粒细胞，它们的作用在很大程度上被忽视了。然而，近年来积累的研究表明中性粒细胞在动脉粥样硬化形成中发挥作用。此外，越来越多的研究表明中性粒细胞在晚期动脉粥样硬化和/或斑块不稳定中起作用。因此，本简要综述概述了中性粒细胞在动脉粥样硬化早期和晚期的作用。
