微生物群与肺
The microbiome and the lung.
作者信息
Cui Lijia, Morris Alison, Huang Laurence, Beck James M, Twigg Homer L, von Mutius Erika, Ghedin Elodie
机构信息
1 Center for Vaccine Research.
出版信息
Ann Am Thorac Soc. 2014 Aug;11 Suppl 4(Suppl 4):S227-32. doi: 10.1513/AnnalsATS.201402-052PL.
Investigation of the human microbiome has become an important field of research facilitated by advances in sequencing technologies. The lung, which is one of the latest body sites being explored for the characterization of human-associated microbial communities, has a microbiome that is suspected to play a substantial role in health and disease. In this review, we provide an overview of the basics of microbiome studies. Challenges in the study of the lung microbiome are highlighted, and further attention is called to the optimization and standardization of methodologies to explore the role of the lung microbiome in health and disease. We also provide examples of lung microbial communities associated with disease or infection status and discuss the role of fungal species in the lung. Finally, we review studies demonstrating that the environmental microbiome can influence lung health and disease, such as the finding that the diversity of microbial exposure correlates inversely with the development of childhood asthma.
随着测序技术的进步，对人类微生物群的研究已成为一个重要的研究领域。肺部是探索人类相关微生物群落特征的最新身体部位之一，其微生物群被怀疑在健康和疾病中发挥重要作用。在这篇综述中，我们概述了微生物群研究的基础知识。突出了肺部微生物群研究中的挑战，并呼吁进一步关注优化和标准化探索肺部微生物群在健康和疾病中作用的方法。我们还提供了与疾病或感染状态相关的肺部微生物群落的例子，并讨论了真菌物种在肺部的作用。最后，我们回顾了一些研究，这些研究表明环境微生物群可以影响肺部健康和疾病，例如微生物暴露的多样性与儿童哮喘的发展呈负相关这一发现。
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