Spindler Christiano, Cechinel Laura Reck, Basso Carla, Moysés Felipe, Bertoldi Karine, Roesler Rafael, Lovatel Gisele Agustini, Rostirola Elsner Viviane, Siqueira Ionara Rodrigues
Programa de Pós-Graduação Em Ciências Biológicas: Fisiologia, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil.
Cell Mol Neurobiol. 2014 Nov;34(8):1097-101. doi: 10.1007/s10571-014-0096-z. Epub 2014 Aug 24.
Studies have pointed out the relationship between neuroprotective exercise effects and epigenetic mechanisms on the hippocampus. Considering the role of frontal cortex on brain functions, we investigated the impact of different exercise protocols on enzymatic system involved with histone acetylation status, histone acetyltransferases (HATs), and histone desacetylases (HDACs) in frontal cortices from Wistar rats. Male Wistar rats aged 3 months were submitted to a single session or a daily running protocol during 2 weeks. The single session enhanced HAT activity, while the moderate daily exercise protocol reduced the HDAC activity. Our results indicate that frontal cortex is susceptible to epigenetic modulation following exercise and that both exercise protocols seem to induce a histone hyperacetylation condition in this brain area.
研究指出了神经保护运动效应与海马体表观遗传机制之间的关系。考虑到前额叶皮质在脑功能中的作用，我们研究了不同运动方案对Wistar大鼠前额叶皮质中与组蛋白乙酰化状态相关的酶系统、组蛋白乙酰转移酶（HATs）和组蛋白去乙酰化酶（HDACs）的影响。3个月大的雄性Wistar大鼠接受单次运动或为期2周的每日跑步方案。单次运动增强了HAT活性，而适度的每日运动方案降低了HDAC活性。我们的结果表明，运动后前额叶皮质易受表观遗传调控，并且两种运动方案似乎都能在该脑区诱导组蛋白高乙酰化状态。
