Leslie Timothy, Pawloski Lisa, Kallman-Price Jillian, Escheik Carey, Hossain Noreen, Fang Yun, Gerber Lynn H, Younossi Zobair M
Betty and Guy Beatty Center for Integrated Research, Inova Health System, Falls Church, VA, United States; Department of Geography & Geoinformation Science, George Mason University, Fairfax, VA, United States.
Betty and Guy Beatty Center for Integrated Research, Inova Health System, Falls Church, VA, United States; Department of Nutrition and Food Studies, George Mason University, Fairfax, VA, United States.
Ann Hepatol. 2014 Sep-Oct;13(5):533-40.
Obesity, a complex disease determined both by genetic and environmental factors, is strongly associated with NAFLD, and has been demonstrated to have a negative impact on HCV and other chronic liver diseases (CLD).
This study assessed the association between type and location of food sources and chronic liver disease (CLD) using Geographic Information Systems (GIS).
CLD patients completed surveys [267 subjects, 56.5% female, age 55.8 ± 12.0, type of CLD: 36.5% hepatitis C (HCV), 19.9% hepatitis B (HBV), 19.9% non-alcoholic fatty liver disease (NAFLD); primary food source (PFS): 80.8% grocery store, secondary: 26.2% bulk food store, tertiary: 20.5% restaurants; fresh food (FF): 83%, pre-packaged (PP) 8.7%, already prepared (AP) 8.3%]. FF consumers had significantly fewer UEH servings/month (p = 0.030) and lived further away from convenience stores (1.69 vs. 0.95 km, p = 0.0001). Stepwise regression reveals the lowest FF consumers were NAFLD patients, subjects with UEH or restaurants and ethnic food stores as their PFS (R = 0.557, p = 0.0001). Eating already-packaged foods and utilizing restaurants or ethnic food stores as the PFS positively correlated with NAFLD (R = 0.546, p = 0.0001).
Environmental food source measures, including type and density, should be included when examining areas hyper-saturated with a variety of food options. In hyper-saturated food environments, NAFLD patients consume more prepared food and less FF. CLD patients with UEH also eat significantly more prepared food and frequent restaurants and ethnic food stores as their PFS.
肥胖是一种由遗传和环境因素共同决定的复杂疾病，与非酒精性脂肪性肝病密切相关，并已被证明对丙型肝炎病毒（HCV）和其他慢性肝病（CLD）有负面影响。
本研究使用地理信息系统（GIS）评估食物来源的类型和位置与慢性肝病（CLD）之间的关联。
CLD患者完成了调查[267名受试者，56.5%为女性，年龄55.8±12.0岁，CLD类型：36.5%为丙型肝炎（HCV），19.9%为乙型肝炎（HBV），19.9%为非酒精性脂肪性肝病（NAFLD）；主要食物来源（PFS）：80.8%为杂货店，次要来源：26.2%为散装食品店，第三来源：20.5%为餐馆；新鲜食品（FF）：83%，预包装食品（PP）8.7%，即食食品（AP）8.3%]。FF消费者每月食用的不健康食品份数显著较少（p = 0.030），且居住距离便利店较远（1.69对0.95公里，p = 0.0001）。逐步回归显示，FF消费量最低的是NAFLD患者、以不健康食品或餐馆及民族食品店为PFS的受试者（R = 0.557，p = 0.0001）。食用预包装食品并以餐馆或民族食品店为PFS与NAFLD呈正相关（R = 0.546，p = 0.0001）。
在研究食物选择多样的高饱和区域时，应纳入包括类型和密度在内的环境食物来源指标。在高饱和食物环境中，NAFLD患者食用更多即食食品，而FF较少。有不健康食品的CLD患者也食用显著更多的即食食品，并经常光顾餐馆和民族食品店作为他们的PFS。
