前列腺素类似物对上皮细胞增殖和异种移植物生长的影响。
Influence of prostaglandin analogues on epithelial cell proliferation and xenograft growth.
作者信息
Tutton P J, Barkla D H
出版信息
Br J Cancer. 1980 Jan;41(1):47-51. doi: 10.1038/bjc.1980.6.
Abstract
The influence of two prostaglandin (PG) analogues, 16,16-dimethyl PG E2 and 16,16-dimethyl PG F2 alpha and of the cyclo-oxygenase inhibitor, flurbiprofen, on epithelial cell proliferation was assessed using a stathmokinetic technique. The epithelia examined were those of the jejunal crypts, the colonic crypts and that of dimethylhydrazine-induced adenocarcinomas of rat colon. The influence of the two prostaglandin analogues, and of flurbiprofen, on the growth of a human colorectal tumour propagated as xenografts in immune-deprived mice was also assessed. The PG E2 analogue transiently inhibited xenograft growth, but was without effect on the mitotic rate in the rat tissues. The PG F2 alpha analogue was also found to inhibit xenograft growth but, unlike the PG E2 analogue, it was found to be a strong inhibitor of cell proliferation in rat colonic tumours, and an accelerator of proliferation in jejunal-crypt cells. The only statistically significant effect of flurbiprofen was to accelerate cell division in the rat colonic tumours.
摘要
使用细胞分裂动力学技术评估了两种前列腺素（PG）类似物，即16,16-二甲基PG E2和16,16-二甲基PG F2α以及环氧化酶抑制剂氟比洛芬对上皮细胞增殖的影响。所检查的上皮组织包括空肠隐窝、结肠隐窝以及二甲基肼诱导的大鼠结肠腺癌的上皮组织。还评估了这两种前列腺素类似物以及氟比洛芬对在免疫缺陷小鼠中作为异种移植生长的人结肠肿瘤生长的影响。PG E2类似物短暂抑制异种移植生长，但对大鼠组织中的有丝分裂率没有影响。还发现PG F2α类似物抑制异种移植生长，但与PG E2类似物不同，它是大鼠结肠肿瘤中细胞增殖的强抑制剂，是空肠隐窝细胞增殖的促进剂。氟比洛芬唯一具有统计学意义的作用是加速大鼠结肠肿瘤中的细胞分裂。
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