Ishii K, Himizu M, Ono F, Yamamoto M, Kawai Y, Watanabe K, Iri H
Rinsho Byori. 1989 Dec;37(12):1379-84.
Detection of circulating anticoagulant (CA) is clinically important in patients with SLE, habitual abortion and other hemorrhagic and thrombotic disorders. We have studied CA in 83 patients with such disorders. Thirty-one of 83 (37%) had positive CA and 16 of 83 (19%) had negative CA, while 36 of 83 (44%) showed borderline pattern of CA. The experiment was undertaken to detect CA clearly in patients with borderline CA, by using diluted APTT or PT reagents. When we used 5% diluted reagent in APTT or 50% diluted reagent in PT, constant value of clotting time showed 1.8% or 1.2%, respectively. Seven of 10 with borderline CA cases tested here revealed positive CA by using diluted reagents. Furthermore 2 of remaining 3 with borderline CA cases showed positive anti-cardiolipin antibodies, suggesting of presence of lupus anticoagulants. These results suggest that CA in borderline cases should be considered to be positive and to be possibly derived from lupus anticoagulants.
检测循环抗凝物质（CA）在系统性红斑狼疮（SLE）、习惯性流产以及其他出血性和血栓性疾病患者中具有重要的临床意义。我们对83例患有此类疾病的患者进行了CA检测。83例患者中，31例（37%）CA呈阳性，16例（19%）CA呈阴性，而83例中有36例（44%）显示CA为临界模式。本实验旨在通过使用稀释的活化部分凝血活酶时间（APTT）或凝血酶原时间（PT）试剂，在CA处于临界值的患者中清晰检测出CA。当我们在APTT中使用5%稀释试剂或在PT中使用50%稀释试剂时，凝血时间的恒定值分别显示为1.8%或1.2%。在此检测的10例CA处于临界值的病例中，有7例通过使用稀释试剂显示CA呈阳性。此外，其余3例CA处于临界值的病例中有2例显示抗心磷脂抗体呈阳性，提示存在狼疮抗凝物。这些结果表明，临界病例中的CA应被视为阳性，且可能源自狼疮抗凝物。
