溶酶体相关细胞器作为金属稳态的介质。
Lysosome-related organelles as mediators of metal homeostasis.
作者信息
Blaby-Haas Crysten E, Merchant Sabeeha S
机构信息
From the Department of Chemistry and Biochemistry and
From the Department of Chemistry and Biochemistry and the Institute for Genomics and Proteomics, UCLA, Los Angeles, California 90095.
出版信息
J Biol Chem. 2014 Oct 10;289(41):28129-36. doi: 10.1074/jbc.R114.592618. Epub 2014 Aug 26.
Abstract
Metal ion assimilation is essential for all forms of life. However, organisms must properly control the availability of these nutrients within the cell to avoid inactivating proteins by mismetallation. To safeguard against an imbalance between supply and demand in eukaryotes, intracellular compartments contain metal transporters that load and unload metals. Although the vacuoles of Saccharomyces cerevisiae and Arabidopsis thaliana are well established locales for the storage of copper, zinc, iron, and manganese, related compartments are emerging as important mediators of metal homeostasis. Here we describe these compartments and review their metal transporter complement.
摘要
金属离子同化对所有生命形式都至关重要。然而，生物体必须适当地控制细胞内这些营养素的可用性，以避免因金属错配而使蛋白质失活。为了防止真核生物中供需失衡，细胞内区室含有加载和卸载金属的金属转运蛋白。虽然酿酒酵母和拟南芥的液泡是储存铜、锌、铁和锰的成熟场所，但相关区室正成为金属稳态的重要调节因子。在这里，我们描述这些区室并综述它们的金属转运蛋白组成。
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2
A bacterial iron exporter for maintenance of iron homeostasis.
J Biol Chem. 2014 Jun 6;289(23):16498-507. doi: 10.1074/jbc.M114.571562. Epub 2014 Apr 29.
3
Two-photon imaging of Zn2+ dynamics in mossy fiber boutons of adult hippocampal slices.
Proc Natl Acad Sci U S A. 2014 May 6;111(18):6786-91. doi: 10.1073/pnas.1405154111. Epub 2014 Apr 22.
4
Roles of Agrobacterium tumefaciens membrane-bound ferritin (MbfA) in iron transport and resistance to iron under acidic conditions.
Microbiology (Reading). 2014 May;160(Pt 5):863-871. doi: 10.1099/mic.0.076802-0. Epub 2014 Mar 5.
5
Imaging element distribution and speciation in plant cells.
Trends Plant Sci. 2014 Mar;19(3):183-92. doi: 10.1016/j.tplants.2013.12.001. Epub 2014 Jan 4.
6
Ctr2 regulates biogenesis of a cleaved form of mammalian Ctr1 metal transporter lacking the copper- and cisplatin-binding ecto-domain.
Proc Natl Acad Sci U S A. 2013 Nov 12;110(46):E4279-88. doi: 10.1073/pnas.1311749110. Epub 2013 Oct 28.
7
The endoplasmic reticulum is the main membrane source for biogenesis of the lytic vacuole in Arabidopsis.
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8
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