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尼日利亚伊巴丹血清抗幽门螺杆菌免疫球蛋白A(IgA)与慢性胃炎组织学参数的相关性

Correlation of serum anti-helicobacter pylori immunoglobulin a (IgA) with histological parameters of chronic gastritis in ibadan, Nigeria.

作者信息

Oluwasola Ao, Otegbayo Ja, Ola So, Ebili Ho, Afolabi Ao, Odaibo Gn

机构信息

Department of Pathology, University College Hospital, Ibadan, Nigeria.

Department of Medicine, University College Hospital, Ibadan, Nigeria.

出版信息

Ann Ib Postgrad Med. 2012 Jun;10(1):18-24.

Abstract

BACKGROUND

The seroprevalence of anti-H. pylori IgA antibodies has been reported to vary among populations and in relation to strains of Helicobacter pylori bacterium. However, there has been conflicting reports on the association between IgA serological status and the histological variables of chronic gastritis. This study was therefore conducted to clarify this relationship.

METHOD

Using an ELISA based commercial kit, anti-H. pylori IgA antibody tests were performed on 65 dyspeptic patients and 65 age- and sex-matched controls. The gastric biopsies of these patients were also examined histologically for the degrees of inflammation, activity, intestinal metaplasia and atrophy. The CagA status of the patients had been determined previously.

RESULTS

There was an anti-H. pylori IgA antibody prevalence of 67.7% in dyspeptics and 56.9% in non-dyspeptic individuals. No correlations were observed between serum H. pylori IgA antibody and the graded parameters of chronic gastritis in dyspeptic patients, although twice more patients with mild gastric inflammation were found among IgA positive than among IgA negative patients. However, a statistically significant relationship was established between serum IgA positivity and the CagA status of the patients (p = 0.028).

CONCLUSION

The seroprevalence of anti-H. pylori IgA antibody is high in our environment. Serum IgA status may be associated with milder degrees of gastritis in our patients but a larger cohort of patients is needed to confirm this. There seems to be a good agreement between serum IgA and CagA statuses among dyspeptic patients.

摘要

背景

据报道,抗幽门螺杆菌IgA抗体的血清流行率在不同人群中以及与幽门螺杆菌菌株有关的情况下存在差异。然而,关于IgA血清学状态与慢性胃炎组织学变量之间的关联,一直存在相互矛盾的报道。因此,进行了本研究以阐明这种关系。

方法

使用基于酶联免疫吸附测定(ELISA)的商业试剂盒,对65例消化不良患者和65例年龄及性别匹配的对照者进行抗幽门螺杆菌IgA抗体检测。还对这些患者的胃活检组织进行了炎症程度、活性、肠化生和萎缩的组织学检查。患者的细胞毒素相关基因A(CagA)状态先前已确定。

结果

消化不良患者中抗幽门螺杆菌IgA抗体的流行率为67.7%,非消化不良个体中为56.9%。在消化不良患者中,未观察到血清幽门螺杆菌IgA抗体与慢性胃炎分级参数之间的相关性,尽管IgA阳性患者中轻度胃炎患者的数量是IgA阴性患者中的两倍。然而,血清IgA阳性与患者的CagA状态之间建立了统计学上的显著关系(p = 0.028)。

结论

在我们的环境中,抗幽门螺杆菌IgA抗体的血清流行率很高。血清IgA状态可能与我们患者中较轻程度的胃炎有关,但需要更大规模的患者队列来证实这一点。在消化不良患者中,血清IgA和CagA状态之间似乎有很好的一致性。

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