Parasitology Department, Medical Research Institute, Alexandria University, 165, Horreya Avenue, Hadara, Alexandria, Egypt.
Acta Parasitol. 2021 Sep;66(3):857-862. doi: 10.1007/s11686-020-00330-y. Epub 2021 Feb 17.
In many tropical areas, the coinfection of Schistosoma spp. and other pathogens is frequent. The impact of schistosomiasis on other infections has been demonstrated for several organisms. Infection with the widely spread bacterium, Helicobacter pylori, has been linked to ulcers and tumors of the digestive system with the humoral immune response playing possible modulatory roles. The present study investigated the impact of patent S. mansoni infection on the antibody response to H. pylori.
A total of 100 participants from a schistosomiasis endemic area in Egypt were enrolled in the study. Based on the detection of S. mansoni eggs and H. pylori coproantigen in fecal samples, they were equally divided into four groups: schistosomiasis, concomitant S. mansoni and H. pylori infection, H. pylori infection alone, and healthy controls. Anti-H. pylori IgG and IgA were determined in serum samples using ELISA.
A significantly lower IgA seropositivity rate and significantly lower IgG levels were found in patients with concomitant schistosomiasis (Gp2) compared to those infected only with H. pylori (Gp1).
Concomitant S. mansoni infection with light to moderate intensity alters serological responses to H. pylori. In schistosomiasis endemic areas, the routine examination for H. pylori infection should, therefore, rely on coproantigen level rather than antibody levels. Further studies should investigate histopathological changes and other immunological parameters in coinfection.
在许多热带地区，血吸虫病与其他病原体的合并感染较为常见。有多项研究表明，血吸虫病对其他感染的影响与几种病原体有关。广泛传播的细菌幽门螺杆菌感染与消化道溃疡和肿瘤有关，体液免疫反应可能起到调节作用。本研究旨在探讨有症状的曼氏血吸虫感染对幽门螺杆菌抗体反应的影响。
本研究共纳入 100 名来自埃及血吸虫病流行区的参与者。根据粪便样本中曼氏血吸虫卵和幽门螺杆菌粪抗原的检测结果，将他们等分为四组：单纯血吸虫病组、合并曼氏血吸虫和幽门螺杆菌感染组、单纯幽门螺杆菌感染组和健康对照组。采用 ELISA 法检测血清中抗幽门螺杆菌 IgG 和 IgA。
与单纯感染幽门螺杆菌组（Gp1）相比，合并轻度至中度曼氏血吸虫感染组（Gp2）的 IgA 血清阳性率显著降低，IgG 水平也显著降低。
轻度至中度曼氏血吸虫合并感染改变了对幽门螺杆菌的血清学反应。因此，在血吸虫病流行地区，幽门螺杆菌感染的常规检查应依赖于粪抗原水平，而非抗体水平。进一步的研究应调查合并感染时的组织病理学变化和其他免疫参数。
