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拟南芥核孔复合体的组分在植物生长控制中发挥多种不同作用。

Components of the Arabidopsis nuclear pore complex play multiple diverse roles in control of plant growth.

作者信息

Parry Geraint

机构信息

Institute of Integrative Biology, University of Liverpool, Crown Street, Liverpool L69 7ZB, UK

出版信息

J Exp Bot. 2014 Nov;65(20):6057-67. doi: 10.1093/jxb/eru346. Epub 2014 Aug 27.

DOI:10.1093/jxb/eru346
PMID:25165147
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4203139/
Abstract

The nuclear pore complex (NPC) is a multisubunit protein conglomerate that facilitates movement of RNA and protein between the nucleus and cytoplasm. Relatively little is known regarding the influence of the Arabidopsis NPC on growth and development. Seedling development, flowering time, nuclear morphology, mRNA accumulation, and gene expression changes in Arabidopsis nucleoporin mutants were investigated. Nuclear export of mRNA is differentially affected in plants with defects in nucleoporins that lie in different NPC subcomplexes. This study reveals differences in the manner by which nucleoporins alter molecular and plant growth phenotypes, suggesting that nuclear pore subcomplexes play distinct roles in nuclear transport and reveal a possible feedback relationship between the expression of genes involved in nuclear transport.

摘要

核孔复合体（NPC）是一种多亚基蛋白质聚集体，它促进RNA和蛋白质在细胞核与细胞质之间的移动。关于拟南芥NPC对生长和发育的影响，人们了解相对较少。研究了拟南芥核孔蛋白突变体的幼苗发育、开花时间、核形态、mRNA积累和基因表达变化。位于不同NPC亚复合体中的核孔蛋白有缺陷的植物中，mRNA的核输出受到不同程度的影响。这项研究揭示了核孔蛋白改变分子和植物生长表型的方式存在差异，表明核孔亚复合体在核运输中发挥着不同的作用，并揭示了参与核运输的基因表达之间可能存在反馈关系。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5db4/4203139/a3a973c57577/exbotj_eru346_f0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5db4/4203139/7b973bc73cd4/exbotj_eru346_f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5db4/4203139/fbacee348dbf/exbotj_eru346_f0002.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5db4/4203139/22f4a69bf7e7/exbotj_eru346_f0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5db4/4203139/24b0e4b5c9c0/exbotj_eru346_f0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5db4/4203139/a3a973c57577/exbotj_eru346_f0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5db4/4203139/7b973bc73cd4/exbotj_eru346_f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5db4/4203139/fbacee348dbf/exbotj_eru346_f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5db4/4203139/3a2b6226388a/exbotj_eru346_f0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5db4/4203139/22f4a69bf7e7/exbotj_eru346_f0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5db4/4203139/24b0e4b5c9c0/exbotj_eru346_f0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5db4/4203139/a3a973c57577/exbotj_eru346_f0006.jpg

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