Guo Xiaoqiang, Xia Jiazeng, Deng Kaiyuan
Department of General Surgery and Translational Medicine Center, Nanjing Medical University Affiliated Wuxi Second Hospital, Wuxi, 214002, Jiangsu, China.
Tumour Biol. 2014 Nov;35(11):10591-600. doi: 10.1007/s13277-014-2548-y. Epub 2014 Sep 1.
Gastric cancer (GC) remains a major public health issue as the second leading cause of cancer-related death and the fourth most common cancer worldwide. Although much progress has been achieved in recent years, the early diagnosis and treatment for GC are not yet satisfactory; thus, the prognosis remains poor. Therefore, identification of novel molecules for early diagnosis, prognosis, and treatment is urgently needed. Long non-coding RNAs (lncRNAs) are a new class of non-coding RNAs that participate in a variety of biological processes such as cell proliferation, cell cycle, differentiation, and apoptosis, mainly by regulation of gene expression at various levels, including chromatin, splicing, transcriptional, and post-transcriptional levels. Some lncRNAs are upregulated in cancer and possess oncogenic properties, while others exhibit aberrant low expression and act as tumor suppressors. In this review, we overview the functional roles and regulatory mechanisms of lncRNAs in GC and evaluate their diagnostic, prognostic, and therapeutic values.
胃癌（GC）仍然是一个重大的公共卫生问题，是癌症相关死亡的第二大主要原因，也是全球第四大常见癌症。尽管近年来已取得很大进展，但胃癌的早期诊断和治疗仍不尽人意；因此，其预后仍然很差。因此，迫切需要鉴定用于早期诊断、预后评估和治疗的新分子。长链非编码RNA（lncRNA）是一类新的非编码RNA，主要通过在染色质、剪接、转录和转录后等各个水平调控基因表达，参与细胞增殖、细胞周期、分化和凋亡等多种生物学过程。一些lncRNA在癌症中上调并具有致癌特性，而另一些则表现出异常低表达并充当肿瘤抑制因子。在本综述中，我们概述了lncRNA在胃癌中的功能作用和调控机制，并评估了它们的诊断、预后和治疗价值。
