[Sensitivity of the arthrosporic and microconidial stages of Trichophyton mentagrophytes to griseofulvin and ketoconazole].

With the use of the modified agar dilution method the present author tested the antifungal activity of griseofulvin and ketoconazole to two spored forms of Trichophyton mentagrophytes. No statistically significant differences were found between the sensitivity of microconidia and arthrospores in both preparations tested. MIC and MFC values of griseofulvin and ketoconazole oscillated within a narrow concentration range. An exception was strain TM 1169, which was highly sensitive to ketoconazole (MIC less than or equal to 0.09 mg l-1, MFC = 1.56 mg l-1), but not to griseofulvin. The results suggest that the testing of antifungal agents in vitro in dermatophytes is not influenced by the growth form of the fungus.