Park Donguk, Leem Jonghan, Lee Kyoungmu, Lim Heungkyu, Choi Yeyong, Ahn Jong-Ju, Lim Sinye, Park Jeongim, Choi Kyungho, Lee Naroo, Jung Hyejung, Ha Jongsik, Paek Domyung
Department of Environmental Health, Korea National Open University, 169 Dongsung-dong, Jongno-gu, Seoul 110-791, Republic of Korea.
Environ Health. 2014 Sep 2;13:70. doi: 10.1186/1476-069X-13-70.
This study describes 17 families with 38 lung injury patients (14 males, 24 females; 22 preschool-age children less than six years of age and 16 individuals of 13-50 years) who used disinfectant added to humidifiers in the home.
Clinical examination and humidifier disinfectant-use histories were taken, and a thorough home investigation was performed to assess exposure to humidifier disinfectant.
Nine of the patients (three pregnant females, six preschool-age children) died soon after they first developed lung damage. Six (16%) were pregnant females and 22 (58%) were preschool-aged children younger than six years. The patients used humidifier disinfectant products containing either polyhexamethylene guanidine phosphate (PHMG, n = 36) or oligo(2-(2-ethoxy)ethoxyethyl guanidinium chloride (PGH, n = 2). Twenty-six patients (68%) used the brand "Oxy"®, which contains PHMG. Of the ten patients with fatal lung injury, nine were found to have used PHMG.
Our findings suggest that the use of humidifier disinfectant products containing either PGH or PHMG can cause lung injury, especially in preschool-age children younger than six years and pregnant women.
本研究描述了17个家庭中的38例肺损伤患者（14名男性，24名女性；22名6岁以下学龄前儿童和16名13 - 50岁个体），他们在家中使用了添加在加湿器中的消毒剂。
进行了临床检查并记录了加湿器消毒剂使用史，同时对家庭进行了全面调查以评估加湿器消毒剂暴露情况。
9例患者（3名孕妇，6名学龄前儿童）在首次出现肺损伤后不久死亡。6例（16%）为孕妇，22例（58%）为6岁以下学龄前儿童。患者使用的加湿器消毒剂产品中，含有聚六亚甲基胍磷酸盐（PHMG，n = 36）或低聚（2 -（2 - 乙氧基）乙氧基乙基氯化铵）（PGH，n = 2）。26例患者（68%）使用了含有PHMG的“Oxy”®品牌产品。在10例致命性肺损伤患者中，有9例使用了PHMG。
我们的研究结果表明，使用含有PGH或PHMG的加湿器消毒剂产品会导致肺损伤，尤其是在6岁以下学龄前儿童和孕妇中。
