Yau Vincent M, Lutsky Marta, Yoshida Cathleen K, Lasley Bill, Kharrazi Martin, Windham Gayle, Gee Nancy, Croen Lisa A
Autism Research Program, Division of Research, Kaiser Permanente, 2000 Broadway, Oakland, CA, 94612, USA.
J Autism Dev Disord. 2015 Mar;45(3):719-30. doi: 10.1007/s10803-014-2227-2.
Thyroid hormones are critical for normal brain development. This study examined autism spectrum disorders (ASD) and thyroid stimulating hormone (TSH) levels measured in mid-pregnancy maternal serum and infant blood after birth. Three groups of children born in Orange County, CA in 2000-2001 were identified: ASD (n = 78), developmental delay (n = 45), and general population controls (GP) (n = 149). Samples were retrieved from prenatal and newborn screening specimen archives. Adjusted logistic regression models showed inverse associations between ASD and log transformed TSH levels in maternal serum samples (ASD vs. GP: OR [95 % CI] 0.33 [0.12-0.91], Early Onset ASD vs. GP: 0.31 [0.10-0.98]). Results for thyroid levels in newborn blood samples were similar though not significant (ASD vs. GP: 0.61 [0.18-2.04]).
甲状腺激素对正常大脑发育至关重要。本研究检测了妊娠中期孕妇血清及婴儿出生后血液中的自闭症谱系障碍（ASD）和促甲状腺激素（TSH）水平。确定了2000 - 2001年在加利福尼亚州奥兰治县出生的三组儿童：ASD组（n = 78）、发育迟缓组（n = 45）和一般人群对照组（GP）（n = 149）。样本取自产前和新生儿筛查标本档案。调整后的逻辑回归模型显示，孕妇血清样本中ASD与对数转换后的TSH水平呈负相关（ASD与GP比较：OR [95% CI] 0.33 [0.12 - 0.91]，早发性ASD与GP比较：0.31 [0.10 - 0.98]）。新生儿血液样本中甲状腺水平的结果相似，但不显著（ASD与GP比较：0.61 [0.18 - 2.04]）。
