Motiei-Langroudi Rouzbeh, Sadeghian Homa, Seddighi Amir Saied
Functional Neurosurgery Research Center, Department of Neurosurgery, Shohada-e-Tajrish Hospital, Tajrish Square, Tehran, Iran.
Shefa Neuroscience Research Center, Tehran, Iran.
Asian Spine J. 2014 Aug;8(4):446-52. doi: 10.4184/asj.2014.8.4.446. Epub 2014 Aug 19.
Case-control.
Evaluate clinical and imaging factors which may predict the risk of failure of medical therapy in patients with lumbar disc herniation (LDH).
LDH is a common cause of low back pain and radicular leg pain, with a generally favorable natural course. At present, however, it is not possible to identify patients who may be candidates for surgery in an early stage of their disease by means of clinical signs or diagnostic imaging criteria.
We designed a study investigating patients with untreated low back pain to assess the predictive value of demographic, clinical or imaging findings in identifying patients who finally would meet the classic current criteria for surgery.
Among 134 patients, 80.6% were successfully treated with conservative therapy and 19.4% finally underwent surgery. Sex, occupation, involved root level, presence of Modic changes, osteophytes or annular tears were not significantly different between the 2 groups, while cerebrospinal fluid block, Pfirrmann's grade, location of herniation with regard to the midline, and type of herniation were significantly different. Anteroposterior fragment size was significantly higher and intervertebral foramen height and thecal sac diameters were significantly lower in the surgical group.
Although it is strongly recommended to practice conservative management at first for patients with LDH symptoms, the results of this study shows that higher Pfirrmann's grade, more laterally located discs, extrusion and protrusion herniation types, and larger fragments could predict the risk of conservative treatment failure. This way, unnecessarily prolonged conservative management (beyond 4-8 weeks) may be precluded.
病例对照研究。
评估可能预测腰椎间盘突出症(LDH)患者保守治疗失败风险的临床和影像学因素。
LDH是下腰痛和下肢放射性疼痛的常见原因,其自然病程总体良好。然而,目前尚无法通过临床体征或诊断影像学标准在疾病早期识别可能需要手术的患者。
我们设计了一项研究,调查未经治疗的下腰痛患者,以评估人口统计学、临床或影像学检查结果在识别最终符合当前经典手术标准患者方面的预测价值。
134例患者中,80.6%经保守治疗成功,19.4%最终接受了手术。两组患者在性别、职业、受累神经根节段、是否存在Modic改变、骨赘或椎间盘环撕裂方面无显著差异,而脑脊液梗阻、Pfirrmann分级、椎间盘突出相对于中线的位置以及椎间盘突出类型存在显著差异。手术组的前后位碎片大小显著更高,椎间孔高度和硬脊膜囊直径显著更低。
尽管强烈建议对有LDH症状的患者首先采用保守治疗,但本研究结果表明,较高的Pfirrmann分级、更偏外侧的椎间盘位置、脱出型和突出型椎间盘突出以及较大的碎片可预测保守治疗失败的风险。这样可以避免不必要的长期保守治疗(超过4 - 8周)。