Lin Zhenjian, Koch Michael, Abdel Aziz May Hamdy, Galindo-Murillo Rodrigo, Tianero Ma Diarey, Cheatham Thomas E, Barrows Louis R, Reilly Chris A, Schmidt Eric W
Department of Medicinal Chemistry and ‡Department of Pharmacology and Toxicology, L. S. Skaggs Pharmacy Institute, University of Utah , Salt Lake City, Utah 84112 United States.
Org Lett. 2014 Sep 19;16(18):4774-7. doi: 10.1021/ol502227x. Epub 2014 Sep 4.
A racemic, prenylated polyketide dimer, oxazinin A (1), was isolated from a novel filamentous fungus in the class Eurotiomycetes, and its structure was elucidated spectroscopically. The pentacyclic structure of oxazinin A (1) is a unique combination of benzoxazine, isoquinoline, and a pyran ring. Oxazinin A (1) exhibited antimycobacterial activity and modestly antagonized transient receptor potential (TRP) channels.
从一种新的散囊菌纲丝状真菌中分离出一种外消旋的、异戊烯化聚酮二聚体——恶嗪宁A(1),并通过光谱法阐明了其结构。恶嗪宁A(1)的五环结构是苯并恶嗪、异喹啉和吡喃环的独特组合。恶嗪宁A(1)表现出抗分枝杆菌活性,并对瞬时受体电位(TRP)通道有适度的拮抗作用。