Goodman Cancer Centre, McGill University, 1160 Pine Avenue West, Montreal, Quebec, H3A 1A3, Canada.
1] Goodman Cancer Centre, McGill University, 1160 Pine Avenue West, Montreal, Quebec, H3A 1A3, Canada. [2] Department of Biochemistry, McGill University, 1160 Pine Avenue West, Montreal, Quebec, H3A 1A3, Canada. [3] Department of Medicine, McGill University, 1160 Pine Avenue West, Montreal, Quebec, H3A 1A3, Canada. [4] Department of Oncology, McGill University, 1160 Pine Avenue West, Montreal, Quebec, H3A 1A3, Canada.
Nat Rev Cancer. 2014 Oct;14(10):673-82. doi: 10.1038/nrc3805. Epub 2014 Sep 5.
CUT-like homeobox 1 (CUX1) is a homeobox gene that is implicated in both tumour suppression and progression. The accumulated evidence supports a model of haploinsufficiency whereby reduced CUX1 expression promotes tumour development. Paradoxically, increased CUX1 expression is associated with tumour progression, and ectopic CUX1 expression in transgenic mice increases tumour burden in several tissues. One CUX1 isoform functions as an ancillary factor in base excision repair and the other CUX1 isoforms act as transcriptional activators or repressors. Several transcriptional targets and cellular functions of CUX1 affect tumorigenesis; however, we have yet to develop a mechanistic framework to reconcile the opposite roles of CUX1 in cancer protection and progression.
CUT-like 同源盒 1（CUX1）是一种同源盒基因，它既参与肿瘤抑制，也参与肿瘤进展。越来越多的证据支持杂合不足的模型，即 CUX1 表达减少促进肿瘤发生。矛盾的是，CUX1 表达增加与肿瘤进展有关，并且转基因小鼠中的异位 CUX1 表达会增加几种组织中的肿瘤负担。CUX1 的一种异构体作为碱基切除修复的辅助因子发挥作用，而其他 CUX1 异构体则作为转录激活剂或抑制剂发挥作用。CUX1 的几个转录靶标和细胞功能影响肿瘤发生；然而，我们尚未建立一个机制框架来协调 CUX1 在癌症保护和进展中的相反作用。
