Shahshahan Zahra, Hashemi Leila, Rasouli Ousha
Department of Obstetrics and Gynecology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
J Res Med Sci. 2014 Jun;19(6):537-41.
This study aimed to evaluate the relation between C-reactive protein (CRP), interleukin (IL) 6 and 8 with the response to tocolytic therapy.
A total of 75 singleton pregnant women between 18 and 35 years old, and with symptoms of preterm labor were hospitalized in "Shahid Beheshti" hospital in Isfahan, Iran. Tocolysis in patients was performed first with infusion of 4 g of magnesium sulfate 20% and then 2 g per hour continued. Next, they were followed till delivery time to assess the response to the treatment. Baseline data and serum levels of IL-6 and IL-8 and CRP were all recorded.
A total of 16 patients with symptoms of preterm labor did not respond to the treatment and delivered prematurely and 59 women responded to tocolytic treatment and delivered at term. There was a significant relationship between serum IL-6, IL-8 and CRP levels with response to the treatment in cut-off > 45 for IL-6 [area under the curve [(AUC), 0.894; SE, 0.042; P-value < 0.0001, >171 for IL-8 (AUC, 0.864; SE, 0.059; P-value < 0.0001)] and >1.8 for CRP (AUC, 0.738; SE, 0.076; P-value = 0.001). Also, pairwise comparison of receiver operating characteristic curves between CRP, IL-6, and IL-8 showed that there were no significant differences between areas for IL-6 with IL-8 (P-value = 0.46); IL-6 with CRP (P-value = 0.086); and IL-8 with CRP (P-value = 0.18).
Maternal serum concentrations of IL-6 and IL-8 and CRP can be used as appropriate biomarkers for predicting the response to tocolytic therapy in pregnant women and there were no significant differences between these markers in predicting tocolytic therapy.
本研究旨在评估C反应蛋白（CRP）、白细胞介素（IL）-6和IL-8与宫缩抑制剂治疗反应之间的关系。
共75名单胎妊娠妇女，年龄在18至35岁之间，有早产症状，在伊朗伊斯法罕的“烈士贝赫什提”医院住院。首先给患者输注4克20%的硫酸镁进行宫缩抑制治疗，然后每小时持续输注2克。接下来，对她们进行随访直至分娩，以评估治疗反应。记录基线数据以及IL-6、IL-8和CRP的血清水平。
共有16例有早产症状的患者对治疗无反应并早产，59例妇女对宫缩抑制治疗有反应并足月分娩。当IL-6的临界值>45时[曲线下面积（AUC），0.894；标准误（SE），0.042；P值<0.0001]，IL-8>171时（AUC，0.864；SE，0.059；P值<0.0001），以及CRP>1.8时（AUC，0.738；SE，0.076；P值=0.001），血清IL-6、IL-8和CRP水平与治疗反应之间存在显著关系。此外，CRP、IL-6和IL-8之间的受试者工作特征曲线的成对比较显示，IL-6与IL-8之间的曲线下面积无显著差异（P值=0.46）；IL-6与CRP之间（P值=0.086）；IL-8与CRP之间（P值=0.18）。
孕妇血清中IL-6、IL-8和CRP的浓度可作为预测宫缩抑制剂治疗反应的合适生物标志物，并且这些标志物在预测宫缩抑制剂治疗方面无显著差异。
