Göker Markus, Spring Stefan, Scheuner Carmen, Anderson Iain, Zeytun Ahmet, Nolan Matt, Lucas Susan, Tice Hope, Del Rio Tijana Glavina, Cheng Jan-Fang, Han Cliff, Tapia Roxanne, Goodwin Lynne A, Pitluck Sam, Liolios Konstantinos, Mavromatis Konstantinos, Pagani Ioanna, Ivanova Natalia, Mikhailova Natalia, Pati Amrita, Chen Amy, Palaniappan Krishna, Land Miriam, Hauser Loren, Chang Yun-Juan, Jeffries Cynthia D, Rohde Manfred, Detter John C, Woyke Tanja, Bristow James, Eisen Jonathan A, Markowitz Victor, Hugenholtz Philip, Kyrpides Nikos C, Klenk Hans-Peter, Lapidus Alla
Leibniz Institute DSMZ - German Collection of Microorganisms and Cell Cultures, Braunschweig, Germany.
DOE Joint Genome Institute, Walnut Creek, California, USA.
Stand Genomic Sci. 2014 May 15;9(3):1105-17. doi: 10.4056/sigs.3016383. eCollection 2014 Jun 15.
Thermotoga thermarum Windberger et al. 1989 is a member to the genomically well characterized genus Thermotoga in the phylum 'Thermotogae'. T. thermarum is of interest for its origin from a continental solfataric spring vs. predominantly marine oil reservoirs of other members of the genus. The genome of strain LA3T also provides fresh data for the phylogenomic positioning of the (hyper-)thermophilic bacteria. T. thermarum strain LA3(T) is the fourth sequenced genome of a type strain from the genus Thermotoga, and the sixth in the family Thermotogaceae to be formally described in a publication. Phylogenetic analyses do not reveal significant discrepancies between the current classification of the group, 16S rRNA gene data and whole-genome sequences. Nevertheless, T. thermarum significantly differs from other Thermotoga species regarding its iron-sulfur cluster synthesis, as it contains only a minimal set of the necessary proteins. Here we describe the features of this organism, together with the complete genome sequence and annotation. The 2,039,943 bp long chromosome with its 2,015 protein-coding and 51 RNA genes is a part of the Genomic Encyclopedia of Bacteria and Archaea project.
嗜热栖热袍菌（Thermotoga thermarum）Windberger等人于1989年发现，它是“栖热袍菌门”（Thermotogae）中基因组特征明确的栖热袍菌属的一员。嗜热栖热袍菌因其源自大陆硫磺泉，而该属其他成员主要源自海洋油藏，故而备受关注。LA3T菌株的基因组也为（超）嗜热细菌的系统基因组定位提供了新数据。嗜热栖热袍菌LA3(T)菌株是栖热袍菌属中第四个被测序的模式菌株基因组，也是嗜热栖热袍菌科中第六个在出版物中正式描述的基因组。系统发育分析并未揭示该类群当前分类、16S rRNA基因数据和全基因组序列之间存在显著差异。然而，嗜热栖热袍菌在铁硫簇合成方面与其他栖热袍菌物种有显著不同，因为它仅含有一套最少的必需蛋白质。在此，我们描述该生物体的特征，以及完整的基因组序列和注释。这条长度为2,039,943 bp的染色体，含有2,015个蛋白质编码基因和51个RNA基因，是细菌和古菌基因组百科全书项目的一部分。
