Integrated Omics Institute, Wonkwang University, Seoul, South Korea.
Dongsung Pharmaceuticals, Seoul, South Korea.
Anticancer Res. 2014 Sep;34(9):4657-64.
Cancer is characterized by the dysregulation of cell signaling pathways at several steps. The majority of current anticancer therapies involve the modulation of a single target. A tumor-targeting drug-delivery system consists of a tumor detection moiety and a cytotoxic material joined directly or through a suitable linker to form a conjugate. Photodynamic therapy has been used for more than 100 years to treat tumors. One of the present goals of photodynamic therapy research is to enhance the selective targeting of tumor cells in order to reduce the risk and extension of unwanted side-effects, caused by normal cell damage. Sonodynamic therapy is a promising new treatment for patients with cancer. It treats cancer with ultrasound and sonosensitive agents. Porphyrin compounds often serve as photosensitive and sonosensitive agents. The combination of these two methods makes cancer treatment more effective. The present review provides an overview of photodynamic therapy, sonodynamic therapy, sono-photodynamic therapy and the four sensitizers which are suitable candidates for combined sono-photodynamic therapy.
癌症的特征是细胞信号通路在多个步骤失调。目前大多数的抗癌疗法都涉及到单一靶点的调节。肿瘤靶向药物递送系统由肿瘤检测部分和细胞毒性物质组成，直接或通过合适的连接子连接形成缀合物。光动力疗法已经使用了 100 多年来治疗肿瘤。光动力疗法研究的当前目标之一是增强肿瘤细胞的选择性靶向，以降低因正常细胞损伤而引起的不必要的副作用的风险和范围。声动力学疗法是一种治疗癌症的有前途的新方法。它使用超声和声敏剂治疗癌症。卟啉化合物通常用作光敏和超声敏剂。这两种方法的结合使癌症治疗更有效。本综述概述了光动力疗法、声动力学疗法、声动力疗法和适合联合声动力疗法的四种敏化剂。
