益生菌植物乳杆菌和膳食纤维对化学诱导的乳腺癌发生的预防作用。
Preventive effects of probiotic bacteria Lactobacillus plantarum and dietary fiber in chemically-induced mammary carcinogenesis.
机构信息
Institute of Biology and Ecology, Faculty of Science, P.J. Šafárik University, Košice, Slovak Republic
Department of Forensic Medicine, Faculty of Medicine, P.J. Šafárik University, Košice, Slovak Republic.
出版信息
Anticancer Res. 2014 Sep;34(9):4969-75.
AIM
The purpose of the present study was to evaluate the chemopreventive efficacy of a new probiotic bacterial strain, Lactobacillus plantarum LS/07 (PRO), prebiotic oligofructose-enriched inulin (PRE) and PRO-PRE combination in a rat model of breast cancer.
MATERIALS AND METHODS
Mammary carcinogenesis was induced by 7,12-dimethylbenz[a]anthracene (DMBA). Daily oral administration of PRO (at a dose of 8.4×10(8) c.f.u./rat) and PRE (in the diet, 20 g/kg) started two weeks before the first DMBA dose and lasted until the end of the experiment (16 weeks).
RESULTS
Administration of PRO, PRE and PRO-PRE combination significantly suppressed the tumor frequency, increased Cd4(+) T-cells in tumor tissue and reduced serum tumor necrosis factor-α concentration. In PRO and PRO-PRE groups, the decline of Cd8(+) T-cells in blood and their increase in tumor tissue was observed.
CONCLUSION
Long-term administration of Lactobacillus plantarum LS/07 with and without inulin is effective against breast cancer, at least partially, through immunomodulatory mechanisms.
目的
本研究旨在评估新型益生菌菌株植物乳杆菌 LS/07（PRO）、富含低聚果糖的菊粉（PRE）和 PRO-PRE 联合在乳腺癌大鼠模型中的化学预防功效。
材料与方法
采用 7,12-二甲基苯并蒽（DMBA）诱导乳腺癌发生。PRO（剂量为 8.4×10(8) c.f.u./rat）和 PRE（饮食中 20 g/kg）的每日口服给药在第一次 DMBA 剂量前两周开始，并持续到实验结束（16 周）。
结果
PRO、PRE 和 PRO-PRE 联合给药显著抑制肿瘤发生率，增加肿瘤组织中的 CD4(+) T 细胞，并降低血清肿瘤坏死因子-α浓度。在 PRO 和 PRO-PRE 组中，观察到血液中 CD8(+) T 细胞的下降及其在肿瘤组织中的增加。
结论
长期给予植物乳杆菌 LS/07 与菊粉联合或不联合可通过免疫调节机制有效防治乳腺癌。
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