Wu Colleen, Giaccia Amato J, Rankin Erinn B
Division of Radiation and Cancer Biology, Department of Radiation Oncology, Center for Clinical Sciences Research, Stanford University, Stanford, CA, 94303-5152, USA.
Curr Osteoporos Rep. 2014 Dec;12(4):428-32. doi: 10.1007/s11914-014-0236-x.
Osteoblasts are an important cellular component of the bone microenvironment controlling bone formation and hematopoiesis. Understanding the cellular and molecular mechanisms by which osteoblasts regulate these processes is a rapidly growing area of research given the important implications for bone therapy, regenerative medicine, and hematopoietic stem cell transplantation. Here we summarize our current knowledge regarding the cellular and molecular crosstalk driving bone formation and hematopoiesis and will discuss the implications of a recent finding demonstrating that osteoblasts are a cellular source of erythropoietin .
成骨细胞是骨微环境中控制骨形成和造血的重要细胞成分。鉴于其对骨治疗、再生医学和造血干细胞移植具有重要意义，了解成骨细胞调节这些过程的细胞和分子机制是一个快速发展的研究领域。在此，我们总结了目前关于驱动骨形成和造血的细胞和分子相互作用的知识，并将讨论最近一项发现的意义，该发现表明成骨细胞是促红细胞生成素的细胞来源。
