Maier Gerrit Steffen, Horas Konstantin, Seeger Jörn Bengt, Roth Klaus Edgar, Kurth Andreas Alois, Maus Uwe
Department of Trauma Surgery, Justus-Liebig-University, Giessen, Germany,
Int Orthop. 2015 Apr;39(4):787-92. doi: 10.1007/s00264-014-2519-3. Epub 2014 Sep 10.
The purpose of this observational study was to evaluate serum levels of 25-OH-D of elderly patients presenting with orthopaedic illness. Furthermore, we enquired about potential confounders and risk factors of hypovitaminosis D in comorbidities and daily medication of the elderly.
Vitamin D levels in 1,083 patients aged >70 years and admitted to an orthopaedic surgery department were measured. Univariate and multivariate analyses were used to assess risk factors for insufficient vitamin D levels.
Overall, 86 % of patients had insufficient serum levels of 25-OH-D and >60 % were vitamin D deficient. Serum vitamin D levels were lower during winter and months with fewer sunshine hours. Patients presenting with obesity, hypertension and osteoporosis were more likely to have low vitamin D levels.
We found a high prevalence of hypovitaminosis D in elderly, nonhospitalized orthopaedic patients. Given the well-known effects of vitamin D on bone metabolism and muscle health, as well as its nonskeletal effects, vitamin D insufficiency may have a negative impact.
本观察性研究旨在评估患有骨科疾病的老年患者的血清25-羟基维生素D水平。此外，我们还探究了老年患者合并症及日常用药中维生素D缺乏的潜在混杂因素和风险因素。
对1083名年龄大于70岁且入住骨科手术科室的患者的维生素D水平进行了测量。采用单因素和多因素分析来评估维生素D水平不足的风险因素。
总体而言，86%的患者血清25-羟基维生素D水平不足，超过60%的患者维生素D缺乏。冬季及日照时间较少的月份，血清维生素D水平较低。患有肥胖症、高血压和骨质疏松症的患者更有可能维生素D水平较低。
我们发现非住院骨科老年患者中维生素D缺乏症的患病率很高。鉴于维生素D对骨代谢和肌肉健康的众所周知的影响，以及其非骨骼效应，维生素D不足可能会产生负面影响。
