Su Pen-Hua, Chen Jia-Yuh, Lin Ching-Yi, Chen Hsiao-Yen, Liao Pao-Chi, Ying Tsung-Ho, Wang Shu-Li
Department of Pediatrics, Chung Shan Medical University Hospital, Taichung City, Taiwan; School of Medicine, Chung Shan Medical University, Taichung City, Taiwan; Division of Environmental Health and Occupational Medicine, National Health Research Institutes, Zhunan, Taiwan.
Department of Pediatrics, Chung Shan Medical University Hospital, Taichung City, Taiwan; School of Medicine, Chung Shan Medical University, Taichung City, Taiwan.
PLoS One. 2014 Sep 10;9(9):e102788. doi: 10.1371/journal.pone.0102788. eCollection 2014.
In utero exposure to phthalates may adversely affect reproductive development in children due to the anti-androgenic properties of the pthalates. Accordingly, we aimed to determine the effects of in utero and environmental phthalate exposure on the reproductive development of eight-year-old children. We recruited 180 children in central Taiwan during November 2001 and followed them until August 2009 when all children became eight years old. Birth outcomes were collected. Bone age, hormone concentrations, and reproductive developmental stages were determined. Phthalate metabolite levels, including mono-2-ethylhexyl phthalate [MEHP], mono-n-butyl phthalate [MnBP], and mono-benzyl phthalate [MBzP], were assessed. No significant gender differences were found in in utero phthalate exposure. Maternal urinary levels of phthalate metabolites did not correlate significantly with birth outcomes, physical characteristics, and reproductive hormones of the eight-year-old children. Regarding the urinary phthalate metabolite levels of the eight-year-old children, MEHP correlated significantly with serum progesterone levels. MEHP levels in girls correlated significantly with serum progesterone levels. MnBP correlated significantly with serum FSH in all children. In girls, MnBP correlated with serum FSH, and MBzP correlated with serum progesterone and FSH levels. Urinary phthalate metabolite levels did not correlate with female developmental stages or the development of female reproductive organs. Phthalate metabolites did not correlate with the physical characteristics and reproductive hormones in boys. Therefore, environmental exposure to phthalates, as determined by urinary phthalate metabolite levels of eight-year-old children, may affect reproductive hormone levels in children, indicating that further studies on the environmental health effects of phthalates are warranted.
由于邻苯二甲酸盐具有抗雄激素特性，子宫内暴露于邻苯二甲酸盐可能会对儿童的生殖发育产生不利影响。因此，我们旨在确定子宫内和环境中邻苯二甲酸盐暴露对8岁儿童生殖发育的影响。2001年11月，我们在台湾中部招募了180名儿童，并对他们进行跟踪，直到2009年8月所有儿童年满8岁。收集了出生结局。测定了骨龄、激素浓度和生殖发育阶段。评估了邻苯二甲酸盐代谢物水平，包括单-2-乙基己基邻苯二甲酸酯[MEHP]、单-n-丁基邻苯二甲酸酯[MnBP]和单苄基邻苯二甲酸酯[MBzP]。在子宫内邻苯二甲酸盐暴露方面未发现显著的性别差异。母亲尿液中邻苯二甲酸盐代谢物水平与8岁儿童的出生结局、身体特征和生殖激素无显著相关性。关于8岁儿童尿液中邻苯二甲酸盐代谢物水平，MEHP与血清孕酮水平显著相关。女孩的MEHP水平与血清孕酮水平显著相关。MnBP与所有儿童的血清促卵泡激素显著相关。在女孩中，MnBP与血清促卵泡激素相关，MBzP与血清孕酮和促卵泡激素水平相关。尿液中邻苯二甲酸盐代谢物水平与女性发育阶段或女性生殖器官的发育无关。邻苯二甲酸盐代谢物与男孩的身体特征和生殖激素无关。因此，根据8岁儿童尿液中邻苯二甲酸盐代谢物水平确定的环境中邻苯二甲酸盐暴露可能会影响儿童的生殖激素水平，这表明有必要进一步研究邻苯二甲酸盐对环境健康的影响。
