Moini Ashraf, Bahar Laleh, Ashrafinia Mansour, Eslami Bita, Hosseini Reihaneh, Ashrafinia Narges
Department of Obstetrics and Gynecology, Arash Women's Hospital, Tehran University of Medical Sciences, Tehran, Iran ; Department of Endocrinology and Female Infertility, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran ; Vali-e-Asr Reproductive Health Research, Tehran University of Medical Sciences, Tehran, Iran.
Department of Obstetrics and Gynecology, Arash Women's Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Int J Fertil Steril. 2012 Jan;5(4):235-40. Epub 2012 Mar 20.
Endometriosis is the presence of endometrial glands and stroma in sites other than the uterine cavity, which is associated with infertility. The objective of this study was to evaluate the effect of laparoscopic surgical treatment on clinical pregnancy in infertile women with minimal or mild endometriosis.
This clinical trial study was performed in infertile women who were referred to the gynecological clinic between April 2008 and March 2009. After confirmation of minimal or mild endometriosis by diagnostic laparoscopy, patients were randomly assigned into two groups using consecutively numbered, opaque sealed envelops. The first group consisted of women who only underwent diagnostic laparoscopy (no treatment) before randomization. The second group of patients underwent operative laparoscopies. T-test and chi-square test were used when appropriate. A p-value less than 0.05 was considered statistically significant.
Analysis with 38 patients in each group showed characteristics such as age, body mass index (BMI), and duration of infertility were statistically similar in both groups. At 9 months follow- up, 9 (24%) women who had operative laparoscopies became pregnant compared with 7 (18%) women in the diagnostic laparoscopy group. The pregnancy rate showed no statistically significant difference between both groups (p=0.49). No complications were reported in either group.
The present study suggested that laparoscopic surgical treatment was not superior to diagnostic laparoscopy in pregnancy occurrence in infertile women with minimal and mild endometriosis. (IRCT Number: IRCT201012311952N2).
子宫内膜异位症是指子宫内膜腺体和间质出现在子宫腔以外的部位，与不孕相关。本研究的目的是评估腹腔镜手术治疗对轻度或中度子宫内膜异位症不孕女性临床妊娠的影响。
本临床试验研究针对2008年4月至2009年3月间转诊至妇科门诊的不孕女性进行。经诊断性腹腔镜检查确诊为轻度或中度子宫内膜异位症后，使用连续编号的不透明密封信封将患者随机分为两组。第一组由在随机分组前仅接受诊断性腹腔镜检查（未治疗）的女性组成。第二组患者接受手术腹腔镜检查。在适当情况下使用t检验和卡方检验。p值小于0.05被认为具有统计学意义。
每组38例患者的分析显示，两组在年龄、体重指数（BMI）和不孕持续时间等特征上在统计学上相似。在9个月的随访中，接受手术腹腔镜检查的9名（24%）女性怀孕，而诊断性腹腔镜检查组有7名（18%）女性怀孕。两组的妊娠率在统计学上无显著差异（p = 0.49）。两组均未报告并发症。
本研究表明，对于轻度和中度子宫内膜异位症的不孕女性，腹腔镜手术治疗在妊娠发生率方面并不优于诊断性腹腔镜检查。（伊朗临床试验注册中心编号：IRCT201012311952N2）
