Saykin A J, Janssen R S, Sprehn G C, Kaplan J E, Spira T J, O'Connor B
Department of Psychiatry, University of Pennsylvania, Philadelphia 19104.
J Neuropsychiatry Clin Neurosci. 1991 Summer;3(3):286-98. doi: 10.1176/jnp.3.3.286.
Subjects were 21 men with persistent generalized lymphadenopathy (PGL, n = 13) or AIDS-related complex (ARC, n = 8), who were not receiving anti-retroviral medication, and 21 controls. At baseline, mild cognitive impairment was detected in language, memory, attention, and visual and auditory processing, primarily in patients with ARC. On follow-up, the ARC group showed continued impairment and abnormalities on new measures of distractibility and activities of daily living. Although mild decline in verbal memory was noted for some patients, overall neuropsychological profiles did not show deterioration. Nomenclature for the pattern of mild, stable neuropsychological changes in patients with cognitive symptoms is discussed. Two interdisciplinary panels have recommended the term HIV-1-associated minor cognitive/motor disorder. Unlike the term AIDS dementia, it does not imply progression or a diagnosis of AIDS.
研究对象为21名未接受抗逆转录病毒治疗的男性，其中13人患有持续性全身性淋巴结病（PGL），8人患有艾滋病相关综合征（ARC），另有21名对照者。基线时，主要在ARC患者中检测到语言、记忆、注意力以及视觉和听觉处理方面的轻度认知障碍。随访时，ARC组在新的注意力分散度和日常生活活动测量中显示出持续的障碍和异常。尽管部分患者的言语记忆有轻度下降，但总体神经心理学特征并未显示恶化。文中讨论了认知症状患者轻度、稳定的神经心理学变化模式的命名。两个跨学科小组推荐使用“HIV-1相关轻度认知/运动障碍”这一术语。与“艾滋病痴呆”这一术语不同，它并不意味着病情进展或艾滋病诊断。
