Bornstein R A, Nasrallah H A, Para M F, Whitacre C C, Fass R J
Department of Psychiatry, Ohio State University College of Medicine, Columbus.
J Neuropsychiatry Clin Neurosci. 1994 Spring;6(2):160-4. doi: 10.1176/jnp.6.2.160.
The relationship between duration of illness and neuropsychological performance was examined in 25 asymptomatic HIV-infected men with an estimated date of seroconversion. Mean duration of illness was approximately 2 years. After controlling for CD4 level at the time of neuropsychological examination, duration of illness was correlated with measures of visual attention, mental flexibility, dexterity, auditory information processing, and response fluency, as well as an overall measure of neuropsychological performance. Although these patients performed within normal limits, these data suggest that duration of infection may be related to subtle alterations in neuropsychological performance. These results are discussed with regard to possible mechanisms that implicate gradual accumulation of neurotoxins.
对25名已估算血清转化日期的无症状HIV感染男性患者的病程与神经心理表现之间的关系进行了研究。平均病程约为2年。在对神经心理检查时的CD4水平进行控制后，病程与视觉注意力、心理灵活性、敏捷性、听觉信息处理、反应流畅性的测量指标以及神经心理表现的总体测量指标相关。尽管这些患者的表现处于正常范围内，但这些数据表明感染持续时间可能与神经心理表现的细微改变有关。针对涉及神经毒素逐渐积累的可能机制对这些结果进行了讨论。
