Baroni Argelinda, Castellanos F Xavier
The Child Study Center at NYU Langone Medical Center, NY, NY, USA.
The Child Study Center at NYU Langone Medical Center, NY, NY, USA; Nathan Kline Institute for Psychiatric Research, Orangeburg, NY, USA.
Curr Opin Neurobiol. 2015 Feb;30:1-8. doi: 10.1016/j.conb.2014.08.005. Epub 2014 Sep 15.
The ongoing release of the Human Connectome Project (HCP) data is a watershed event in clinical neuroscience. By attaining a quantum leap in spatial and temporal resolution within the framework of a twin/sibling design, this open science resource provides the basis for delineating brain-behavior relationships across the neuropsychiatric landscape. Here we focus on attention-deficit/hyperactivity disorder (ADHD), which is at least partly continuous across the population, highlighting constructs that have been proposed for ADHD and which are included in the HCP phenotypic battery. We review constructs implicated in ADHD (reward-related processing, inhibition, vigilant attention, reaction time variability, timing and emotional lability) which can be examined in the HCP data and in future 'high definition' clinical datasets.
人类连接组计划（HCP）数据的持续发布是临床神经科学领域的一个分水岭事件。通过在双胞胎/兄弟姐妹设计框架内实现空间和时间分辨率的巨大飞跃，这个开放科学资源为描绘整个神经精神领域的脑-行为关系提供了基础。在这里，我们聚焦于注意力缺陷多动障碍（ADHD），它在人群中至少部分呈连续性，突出了已被提出用于ADHD且包含在HCP表型组中的结构。我们回顾了与ADHD相关的结构（奖励相关加工、抑制、警觉注意力、反应时间变异性、时间感知和情绪不稳定），这些结构可以在HCP数据以及未来的“高清”临床数据集中进行研究。
