麻痹性贝类中毒毒素小鼠生物测定中石房蛤毒素与脱氨甲酰基石房蛤毒素的毒性比较。
Comparison of toxicity between saxitoxin and decarbamoyl saxitoxin in the mouse bioassay for paralytic shellfish poisoning toxins.
作者信息
Suzuki Hodaka, Machii Kenji
机构信息
Division of Biomedical Food Research, National Institute of Health Sciences, 1-18-1 Kamiyoga, Setagaya-ku, Tokyo 158-8501, Japan.
出版信息
J Vet Med Sci. 2014 Nov;76(11):1523-5. doi: 10.1292/jvms.14-0211. Epub 2014 Sep 10.
The mouse bioassay (MBA) for paralytic shellfish poisoning (PSP) toxins has been used in the AOAC Official Method and the official Japanese method. In the AOAC Official Method, the saxitoxin (STX) standard provided by the U.S. Food and Drug Administration (FDA) is used, but no standard is used in the official Japanese method. The objective of this study was to compare the toxicity of decarbamoyl STX (dcSTX), one of the derivatives of STX and a candidate standard for the MBA for PSP toxins in Japan, to that of FDA STX in the MBA platform. In this study, the toxicity of dcSTX was 918.0 ± 44.9 mouse units/µmol, and the relative toxicity ratio of dcSTX to FDA STX based on moles was 0.478.
麻痹性贝类中毒（PSP）毒素的小鼠生物测定法（MBA）已被用于美国公职分析化学师协会（AOAC）的官方方法和日本官方方法中。在AOAC官方方法中，使用的是美国食品药品监督管理局（FDA）提供的石房蛤毒素（STX）标准品，但日本官方方法中未使用标准品。本研究的目的是在MBA平台上比较STX的衍生物之一、日本PSP毒素MBA候选标准品脱氨甲酰STX（dcSTX）与FDA STX的毒性。在本研究中，dcSTX的毒性为918.0±44.9小鼠单位/µmol，基于摩尔数的dcSTX与FDA STX的相对毒性比为0.478。
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