Institute of Biomaterials, Department of Materials Science and Engineering, University of Erlangen-Nuremberg, Cauerstrasse 6, 91058 Erlangen, Germany.
Institute for Mechanics of Materials and Structures, Vienna University of Technology (TU Wien), Karlsplatz 13/202, 1040 Vienna, Austria.
J Mech Behav Biomed Mater. 2014 Dec;40:85-94. doi: 10.1016/j.jmbbm.2014.08.010. Epub 2014 Aug 21.
Highly porous 45S5 Bioglass(®)-based scaffolds with interconnected pore structure are promising candidates for bone tissue engineering due to their bioactivity, biocompatibility, osteogenic and angiogenic effects. In the present study, to ensure the mechanical competence of the 45S5 Bioglass(®)-based scaffolds, their stiffness was adjusted by applying polymer coatings and further crosslinking treatment. A non-destructive ultrasonic technique was used to determine the stiffness of the scaffolds. The stiffness of uncoated scaffolds was shown to increase by applying polymer coatings, and a further increase was achieved by crosslinking the used polymer coatings. All uncoated and polymer-coated scaffolds were confirmed to exhibit stiffness values in the range of reported values in the literature for cancellous bone. A statistical evaluation of combined multiscale ultrasound-nanoindentation measurements indicated that the stiffness of the coated scaffold is directly dependent on the stiffness of the polymer coating.
具有互连通孔结构的高多孔 45S5 生物玻璃（®）基支架由于其生物活性、生物相容性、成骨和血管生成作用，是骨组织工程的有前途的候选者。在本研究中，为了确保 45S5 生物玻璃（®）基支架的机械性能，通过施加聚合物涂层和进一步的交联处理来调整其刚度。使用非破坏性超声技术来确定支架的刚度。结果表明，施加聚合物涂层可使未涂层支架的刚度增加，而交联使用的聚合物涂层则可进一步提高刚度。所有未涂层和聚合物涂层的支架均被证实具有与文献中报道的松质骨相当的刚度值。对超声-纳米压痕多尺度联合测量的统计评估表明，涂层支架的刚度直接取决于聚合物涂层的刚度。
