Massachusetts Institute of Technology, Institute for Medical Engineering and Science, Harvard-MIT Division for Health Sciences and Technology, E25-449 Cambridge, MA, USA.
Massachusetts Institute of Technology, Institute for Medical Engineering and Science, Harvard-MIT Division for Health Sciences and Technology, E25-449 Cambridge, MA, USA; Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Adv Drug Deliv Rev. 2015 Jan;81:169-83. doi: 10.1016/j.addr.2014.09.003. Epub 2014 Sep 16.
microRNAs (miRNAs) show high potential for cancer treatment, however one of the most significant bottlenecks in enabling miRNA effect is the need for an efficient vehicle capable of selective targeting to tumor cells without disrupting normal cells. Even more challenging is the ability to detect and silence multiple targets simultaneously with high sensitivity while precluding resistance to the therapeutic agents. Focusing on the pervasive role of miRNAs, herein we review the multiple nanomaterial-based systems that encapsulate DNA/RNA for miRNA sensing and inhibition in cancer therapy. Understanding the potential of miRNA detection and silencing while overcoming existing limitations will be critical to the optimization and clinical utilization of this technology.
microRNAs (miRNAs) 在癌症治疗方面显示出巨大的潜力，然而，使 miRNA 发挥作用的最显著瓶颈之一是需要一种有效的载体，使其能够选择性地靶向肿瘤细胞，而不破坏正常细胞。更具挑战性的是同时具有高灵敏度检测和沉默多个靶标，同时防止对治疗剂产生耐药性。本文聚焦于 miRNAs 的普遍作用，综述了用于 miRNA 检测和抑制的多种基于纳米材料的系统，这些系统用于癌症治疗中包裹 DNA/RNA。理解 miRNA 检测和沉默的潜力，同时克服现有局限性，对于该技术的优化和临床应用至关重要。
