Vaughan Hannah J, Green Jordan J
Department of Biomedical Engineering, Institute for NanoBioTechnology, and the Translational Tissue Engineering Center, Johns Hopkins University School of Medicine, 400 N Broadway, Baltimore, MD 21231, USA.
Departments of Ophthalmology, Oncology, Neurosurgery, Materials Science & Engineering, and Chemical & Biomolecular Engineering, and the Bloomberg~Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University School of Medicine, 400 N Broadway, Baltimore, MD 21231, USA.
Curr Opin Biomed Eng. 2021 Dec;20. doi: 10.1016/j.cobme.2021.100300. Epub 2021 Jul 15.
There is great interest in developing gene therapies for many disease indications, including cancer. However, successful delivery of nucleic acids to tumor cells is a major challenge, and efficacy is difficult to predict. Cancer theranostics is an approach combining anti-tumor therapy with imaging or diagnostic capabilities, with the goal of monitoring successful delivery and efficacy of a therapeutic agent in a tumor. Successful theranostics must maintain a high degree of anticancer targeting and efficacy while incorporating high-contrast imaging agents that are nontoxic and compatible with clinical imaging modalities. This review highlights recent advancements in theranostic strategies, including imaging technologies and genetic engineering approaches. Graphical Abstract.
人们对开发针对包括癌症在内的多种疾病适应症的基因疗法有着浓厚的兴趣。然而，将核酸成功递送至肿瘤细胞是一项重大挑战，且疗效难以预测。癌症诊疗学是一种将抗肿瘤治疗与成像或诊断能力相结合的方法，其目标是监测治疗剂在肿瘤中的成功递送和疗效。成功的诊疗学必须在纳入无毒且与临床成像模式兼容的高对比度成像剂的同时，保持高度的抗癌靶向性和疗效。本综述重点介绍了诊疗策略的最新进展，包括成像技术和基因工程方法。图形摘要。
