Iraburu M, Civeira M P, Serrano M, Morte S, Castilla A, Prieto J
Department of Internal Medicine, School of Medicine, University of Navarra, Pamplona, Spain.
J Med Virol. 1989 Jan;27(1):39-43. doi: 10.1002/jmv.1890270109.
Suppressor T-cell activity and allogeneic T-cell response to concanavalin A (ConA) were investigated in 46 patients chronically infected with hepatitis B virus (HBV). Thirty-eight patients had chronic active hepatitis, seven of whom were superinfected with Delta virus, and eight were healthy chronic HBV carriers. T-cell suppressor activity was in the normal range in healthy carriers and in patients negative for serum HBV-DNA, independent of the e antigen status. In contrast, the group of patients positive for HBV-DNA exhibited a significant reduction in suppressor activity. Longitudinal studies in patients who cleared serum HBV-DNA demonstrated that suppressor T-cell activity became normal thereafter. These results suggest a relationship between suppressor T-cell function and the stage of viral replication in individuals with chronic HBV infection.
对46例慢性乙型肝炎病毒（HBV）感染者的抑制性T细胞活性及对刀豆蛋白A（ConA）的同种异体T细胞反应进行了研究。38例患者患有慢性活动性肝炎，其中7例重叠感染丁型病毒，8例为健康慢性HBV携带者。健康携带者和血清HBV-DNA阴性的患者，其T细胞抑制活性在正常范围内，与e抗原状态无关。相比之下，HBV-DNA阳性的患者组抑制活性显著降低。对血清HBV-DNA转阴患者的纵向研究表明，此后抑制性T细胞活性恢复正常。这些结果提示，慢性HBV感染个体的抑制性T细胞功能与病毒复制阶段之间存在关联。
