Han Chengkun, Huang Shumin, Guo Jianfeng, Zhuang Xiongjie, Han Haiwei
Department of Neuroradiology, The First Affiliated Hospital of Xiamen University, Fujian, China.
Department of Cardiology, The First Affiliated Hospital of Xiamen University, Fujian, China.
J Magn Reson Imaging. 2015 Jul;42(1):80-6. doi: 10.1002/jmri.24747. Epub 2014 Sep 15.
To determine whether apparent diffusion coefficient (ADC) values obtained using a b-value of 3000 s/mm(2) can be used to differentiate high-grade glioma (HGG) from solitary metastases (SM).
Forty patients underwent conventional magnetic resonance imaging (MRI) and standard and high b-value diffusion-weighted imaging (DWI). Minimum, maximum, and mean ADC values (ADCMIN , ADCMAX , and ADCMEAN , respectively) were measured from ADC maps obtained for the two b-values for each subject. ADC ratios were also measured. A receiver operating characteristic (ROC) curve analysis was used to determine the cutoff ADC value for distinguishing between HGG and SM.
All ADC values for the peritumoral region of the HGGs examined were lower than those for the SM. Furthermore, a larger statistical difference was observed for ADCMIN , ADCMAX , and ADCMEAN values at a b-value of 3000 s/mm(2) versus 1000 s/mm(2) (P < 0.0001, P = 0.0010, and P = 0.0001 versus P = 0.0001, 0.0030, and 0.0002, respectively). A discriminant analysis identified the greatest log likelihood for the ADCMIN values obtained at a b-value of 3000 s/mm(2) , and the cutoff value for differentiating HGG and SM was 0.890 × 10(-3) mm/s(2) .
ADC values from DWI using a high b-value were found to distinguish HGG and SM. The lowest degree of overlap was obtained when an ADCMIN value was obtained at a b-value of 3000 s/mm(2) .
确定使用3000 s/mm²的b值获得的表观扩散系数（ADC）值是否可用于区分高级别胶质瘤（HGG）和孤立性转移瘤（SM）。
40例患者接受了常规磁共振成像（MRI）以及标准和高b值扩散加权成像（DWI）。从每个受试者的两个b值获得的ADC图中测量最小、最大和平均ADC值（分别为ADCMIN、ADCMAX和ADCMEAN）。还测量了ADC比率。采用受试者操作特征（ROC）曲线分析来确定区分HGG和SM的临界ADC值。
所检查的HGG瘤周区域的所有ADC值均低于SM的ADC值。此外，在b值为3000 s/mm²时与1000 s/mm²时相比，ADCMIN、ADCMAX和ADCMEAN值的统计学差异更大（分别为P < 0.0001、P = 0.0010和P = 0.0001，而P = 0.0001、0.0030和0.0002）。判别分析确定在b值为3000 s/mm²时获得的ADCMIN值具有最大对数似然性，区分HGG和SM的临界值为0.890×10⁻³ mm²/s。
发现使用高b值的DWI获得的ADC值可区分HGG和SM。当在b值为3000 s/mm²时获得ADCMIN值时，重叠程度最低。
