Research Group EnVOC, Department of Sustainable Organic Chemistry and Technology, Faculty of Bioscience Engineering, Ghent University, Coupure Links 653, B-9000 Ghent, Belgium.
Research Group EnVOC, Department of Sustainable Organic Chemistry and Technology, Faculty of Bioscience Engineering, Ghent University, Coupure Links 653, B-9000 Ghent, Belgium.
Sci Total Environ. 2014 Dec 1;500-501:250-69. doi: 10.1016/j.scitotenv.2014.08.075. Epub 2014 Sep 16.
The aim of this review paper is to provide a comprehensive overview of different chemical and environmental aspects concerning fluoroquinolone antibiotics as emerging contaminants. A literature survey has been performed based on 204 papers from 1998 to mid-2013, resulting in a dataset consisting out of 4100 data points related to physical-chemical properties, environmental occurrence, removal efficiencies, and ecotoxicological data. In a first part, an overview is given on relevant physical-chemical parameters to better understand the behavior of fluoroquinolones during wastewater treatment and in the environment. Secondly, the route of these antibiotics after their application in both human and veterinary surroundings is discussed. Thirdly, the occurrence of fluoroquinolone residues is discussed for different environmental matrices. The final part of this review provides a tentative risk assessment of fluoroquinolone compounds and their transformation products in surface waters by means of hazard quotients. Overall, this review shows that fluoroquinolone antibiotics have a wide spread use and that their behavior during wastewater treatment is complex with an incomplete removal. As a result, it is observed that these biorecalcitrant compounds are present in different environmental matrices at potentially hazardous concentrations for the aquatic environment. The latter calls for actions on both the consumption as well as the wastewater treatment aspect to diminish the discharge of these biological active compounds.
本文旨在全面概述有关氟喹诺酮类抗生素作为新兴污染物的化学和环境方面。根据 1998 年至 2013 年年中 204 篇论文进行了文献综述，得出了包含 4100 个数据点的数据集，这些数据点与物理化学性质、环境出现、去除效率和生态毒理学数据有关。在第一部分中，概述了相关的物理化学参数，以便更好地了解氟喹诺酮类抗生素在废水处理和环境中的行为。其次，讨论了这些抗生素在人类和兽医环境中的应用途径。第三，讨论了不同环境基质中氟喹诺酮残留的情况。本文的最后一部分通过危害系数对地表水氟喹诺酮化合物及其转化产物进行了暂定风险评估。总体而言，本文综述表明，氟喹诺酮类抗生素的使用范围很广，其在废水处理过程中的行为非常复杂，去除不完全。因此，观察到这些生物难降解化合物以对水生环境具有潜在危害的浓度存在于不同的环境基质中。这就需要在消费和废水处理方面采取行动，以减少这些生物活性化合物的排放。
