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肺动脉血栓切除术治疗亚大面积和大面积肺栓塞

Pulmonary embolectomy in the treatment of submassive and massive pulmonary embolism.

作者信息

Worku Berhane, Gulkarov Iosif, Girardi Leonard N, Salemi Arash

机构信息

Department of Cardiothoracic Surgery, Weill Cornell Medical College/New York Presbyterian Hospital, New York, N.Y., USA.

出版信息

Cardiology. 2014;129(2):106-10. doi: 10.1159/000363647. Epub 2014 Sep 10.

Abstract

OBJECTIVES

Significant improvements in outcomes after pulmonary embolectomy have resulted in a broadening of indications. We reviewed our experience with pulmonary embolectomy over the past 12 years with an emphasis on preoperative comorbidities and postoperative morbidity and mortality.

METHODS

All patients undergoing pulmonary embolectomy over the past 12 years at our institution were analyzed via retrospective chart review. Data on preoperative characteristics, operative procedures and postoperative outcomes were collected.

RESULTS

Twenty patients underwent pulmonary embolectomy between 1999 and 2011. The average age was 56 years (range 24-81) and 10 patients (50%) were female. All patients demonstrated right ventricular dysfunction and 19 (95%) demonstrated contraindications to thrombolysis. Twelve patients (60%) demonstrated intermittent hypotension, 4 (20%) required intubation and 3 (15%) demonstrated preoperative or intraoperative cardiac arrest. Survival to discharge was 95%.

CONCLUSIONS

Pulmonary embolectomy has been shown to be safe and effective in the treatment of massive pulmonary embolism (PE). We achieved a 95% survival rate in a cohort of patients with significant comorbid status. Pulmonary embolectomy should be considered early in the therapeutic algorithm for patients with submassive PE presenting with right ventricular dysfunction to prevent progression. It can also be performed with good outcomes in those already suffering hemodynamic compromise.

摘要

目的

肺血栓切除术的疗效显著改善,使得其适应证有所拓宽。我们回顾了过去12年里我们在肺血栓切除术方面的经验,重点关注术前合并症以及术后的发病率和死亡率。

方法

通过回顾性病历审查,分析了过去12年里在我们机构接受肺血栓切除术的所有患者。收集了术前特征、手术过程及术后结果的数据。

结果

1999年至2011年间,20例患者接受了肺血栓切除术。平均年龄为56岁(范围24 - 81岁),10例患者(50%)为女性。所有患者均表现出右心室功能障碍,19例(95%)表现出溶栓治疗的禁忌证。12例患者(60%)表现出间歇性低血压,4例(20%)需要插管,3例(15%)表现出术前或术中心脏骤停。出院生存率为95%。

结论

肺血栓切除术已被证明在治疗大面积肺栓塞(PE)方面是安全有效的。我们在一组合并症严重的患者中实现了95%的生存率。对于出现右心室功能障碍的次大面积PE患者,在治疗方案中应尽早考虑肺血栓切除术以防止病情进展。对于已经出现血流动力学不稳定的患者,实施该手术也能取得良好效果。

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