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患有和未患先兆子痫的女性中母体、胎盘和胎儿对双酚A的暴露情况。

Maternal, placental and fetal exposure to bisphenol A in women with and without preeclampsia.

作者信息

Leclerc François, Dubois Marie-France, Aris Aziz

机构信息

Department of Obstetrics and Gynecology .

出版信息

Hypertens Pregnancy. 2014 Aug;33(3):341-8. doi: 10.3109/10641955.2014.892607. Epub 2014 Apr 11.

DOI:10.3109/10641955.2014.892607
PMID:24724919
Abstract

OBJECTIVES

We aimed to investigate potential association between the exposure of bisphenol A (BPA) and preeclampsia.

METHODS

Concentrations of BPA were assessed in 58 pregnancies including 35 normotensive and 23 preeclamptic women, using a highly sensitive gas chromatography-mass spectrometry (GC-MS) method.

RESULTS

BPA was detected in maternal blood, fetal blood and placental tissue; and actual concentrations of BPA were determined. Interestingly, significant accumulation of BPA in the placentas of women with preeclampsia compared to normotensive women has been shown.

CONCLUSIONS

This is the first study to highlight a significant correlation between preeclampsia and a high accumulation of BPA in the placenta.

摘要

目的

我们旨在研究双酚A（BPA）暴露与子痫前期之间的潜在关联。

方法

采用高灵敏度气相色谱-质谱联用（GC-MS）方法，对58例孕妇（包括35例血压正常者和23例子痫前期患者）的双酚A浓度进行评估。

结果

在母体血液、胎儿血液和胎盘组织中检测到了双酚A，并测定了其实际浓度。有趣的是，与血压正常的女性相比，子痫前期女性的胎盘中有双酚A的显著蓄积。

结论

这是第一项强调子痫前期与胎盘中双酚A高蓄积之间存在显著相关性的研究。

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