CAS Key Laboratory of Coastal Environmental Processes and Ecological Remediation, Yantai Institute of Coastal Zone Research (YIC), Chinese Academy of Sciences (CAS); Shandong Key Laboratory of Coastal Environmental Processes, YICCAS, Yantai 264003, P. R. China.
University of Chinese Academy of Sciences, Beijing 100049, P. R. China.
Aging (Albany NY). 2020 Feb 7;12(3):2723-2746. doi: 10.18632/aging.102773.
Mild stress-induced hormesis, as a promising strategy to improve longevity and healthy aging, meets both praise and criticism. To comprehensively assess the applicability of hormesis in aging intervention, this meta-analysis was conducted focusing on the effect of hormesis on . Twenty-six papers involving 198 effect size estimates met the inclusion criteria. Meta-analytic results indicated that hormesis could significantly extend the mean lifespan of by 16.7% and 25.1% under normal and stress culture conditions ( < 0.05), respectively. The healthspan assays showed that hormesis remarkably enhanced the bending frequency and pumping rate of worms by 28.9% and 7.0% ( < 0.05), respectively, while effectively reduced the lipofuscin level by 15.9% ( < 0.05). The obviously increased expression of (1.66-fold) and its transcriptional targets, including (2.46-fold), (2.32-fold) and (2.88-fold) ( < 0.05), was one of the molecular mechanisms underlying these positive effects of hormesis. This meta-analysis provided strong evidence for the anti-aging role of hormesis, highlighting its lifespan-prolonging, healthspan-enhancing and resistance-increasing effects on . Given that was highly conservative, hormesis offered the theoretical possibility of delaying intrinsic aging through exogenous intervention among humans.
轻度应激诱导的有益效应作为一种有前途的延长寿命和健康衰老的策略，受到了赞誉和批评。为了全面评估有益效应在衰老干预中的适用性，本研究聚焦于有益效应在衰老干预中的作用，进行了这项荟萃分析。共有 26 篇论文涉及 198 个效应量估计值符合纳入标准。荟萃分析结果表明，在正常和应激培养条件下，有益效应分别显著延长 的平均寿命 16.7%和 25.1%（ < 0.05）。健康寿命测定结果表明，有益效应分别显著提高线虫的弯曲频率和泵动率 28.9%和 7.0%（ < 0.05），有效降低脂褐素水平 15.9%（ < 0.05）。有益效应的这些积极作用的一个分子机制是 （1.66 倍）及其转录靶基因，包括 （2.46 倍）、 （2.32 倍）和 （2.88 倍）（ < 0.05）的明显增加表达。这项荟萃分析为有益效应的抗衰老作用提供了有力证据，突出了其对 的延长寿命、增强健康寿命和提高抗性的作用。鉴于 高度保守，有益效应通过外源性干预为人类提供了延缓内在衰老的理论可能性。
