异常威克汉姆酵母性角膜炎对局部抗真菌药物米卡芬净治疗有效。

Wickerhamomyces anomalus fungal keratitis responds to topical treatment with antifungal micafungin.

机构信息

Department of Ophthalmology, Keio University School of Medicine, Japan.

出版信息

J Infect Chemother. 2015 Feb;21(2):141-3. doi: 10.1016/j.jiac.2014.08.019. Epub 2014 Sep 16.

DOI:10.1016/j.jiac.2014.08.019

Abstract

We describe a 91-year-old woman who suffered from fungal keratitis after corneal transplantation. The causative organism was identified as Wickerhamomyces anomalus (formerly Pichia anomala or Hansenula anomala) on the basis of morphological characteristics and the sequence of the internal transcribed spacer region of the ribosomal RNA gene. The patient was successfully treated with topical micafungin (MCFG) only. We present the first report of a case of W. anomalus fungal keratitis that responded to topical treatment with the antifungal MCFG.

摘要

我们描述了一位 91 岁女性在角膜移植后发生真菌性角膜炎的病例。根据形态学特征和核糖体 RNA 基因内转录间隔区的序列，鉴定病原体为异常威克汉姆酵母（以前称为异常毕赤酵母或异常汉逊酵母）。该患者仅通过局部应用米卡芬净（MCFG）治疗即获得成功。我们报告了首例异常威克汉姆酵母真菌性角膜炎的病例，该病例对 MCFG 这种抗真菌药物的局部治疗有反应。