儿童缺铁性贫血与单纯性热性惊厥之间的关系。
The relationship between iron deficiency anemia and simple febrile convulsion in children.
作者信息
Yousefichaijan Parsa, Eghbali Aziz, Rafeie Mohammad, Sharafkhah Mojtaba, Zolfi Mohaddeseh, Firouzifar Mohammadreza
机构信息
Department of Pediatrics, School of Medicine, Arak University of Medical Sciences, Arak, Iran.
Department of Biostatistics and Epidemiology, School of Medicine, Arak University of Medical Sciences, Arak, Iran.
出版信息
J Pediatr Neurosci. 2014 May;9(2):110-4. doi: 10.4103/1817-1745.139276.
BACKGROUND
Simple febrile convulsion is the most common disease of the nervous system in children. There are hypotheses that iron deficiency may affect febrile convulsion and the threshold of neuron excitation.
AIMS
This study was conducted with the objective of finding the effects of iron deficiency anemia on simple febrile convulsion episodes.
SETTINGS AND DESIGN
The study was conducted at AmirKabir Hospital of Arak Medical Sciences University, Arak, Iran. This is a case-control study.
MATERIALS AND METHODS
In this study, 382 children who were selected according to our inclusion and exclusion factors, were divided into two groups of case (febrile convulsion) and control (other factors causing fever) by their cause of hospitalization. After fever subsided, 5 ml blood sample was taken from each child and complete blood count and iron profile tests were performed.
STATISTICAL ANALYSIS
The results were interpreted using descriptive statistics and independent t-test.
RESULTS
The prevalence of anemia in the group with febrile convulsion was significantly less than that in the control group: 22.5% of the children in the group with febrile convulsion and 34% in the control group exhibited anemia (P < 0.001). Moreover, the group with febrile convulsion had significantly higher blood indices, such as Hb, Hct, MCV, MCH, and MCHC, compared to the control group (P < 0.001).
CONCLUSIONS
Iron deficiency can prevent febrile convulsion in children and probably increases the threshold of neuron excitation in fever.
背景
单纯性热性惊厥是儿童最常见的神经系统疾病。有假说认为缺铁可能影响热性惊厥及神经元兴奋阈值。
目的
本研究旨在探讨缺铁性贫血对单纯性热性惊厥发作的影响。
地点与设计
本研究在伊朗阿拉克医科大学阿米尔卡比尔医院进行。这是一项病例对照研究。
材料与方法
本研究中，根据纳入和排除标准选取的382名儿童，按住院原因分为病例组（热性惊厥）和对照组（其他发热原因）。热退后，从每个儿童采集5ml血样，进行血常规和铁代谢指标检测。
统计分析
结果采用描述性统计和独立t检验进行分析。
结果
热性惊厥组贫血患病率显著低于对照组：热性惊厥组22.5%的儿童和对照组34%的儿童患有贫血（P<0.001）。此外，热性惊厥组的血液指标如血红蛋白、红细胞压积、平均红细胞体积、平均红细胞血红蛋白含量和平均红细胞血红蛋白浓度显著高于对照组（P<0.001）。
结论
缺铁可预防儿童热性惊厥，可能提高发热时神经元兴奋阈值。
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