Ghasemi Fateme, Valizadeh Fateme, Taee Nadere
Nursing Faculty, Lorestan University of Medical Sciences, khorramabad, Iran.
PhD student of Nursing Education, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Iran J Child Neurol. 2014 Spring;8(2):38-44.
Considering the recurrence of febrile seizure and costs for families, many studies have attempted to identify its risk factors. Some recent studies have reported that anemia is more common in children with febrile convulsion, whereas others have reported that iron deficiency raises the seizure threshold. This study was done to compare iron-deficiency anemia in children with first FS with children having febrile illness alone and with healthy children.
MATERIALS & METHODS: This case-control study evaluated 300 children in three groups (first FS, febrile without convulsion, and healthy) in Khoramabad Madani Hospital from September 2009 to September 2010. Body temperature on admission was measured using the tympanic method. CBC diff, MCV, MCH, MCHC, serum iron, plasma ferritin and TIBC tests were performed for all participants. Data were analyzed by frequency, mean, standard deviation, ANOVA, and chi-square statistical tests. Odds ratios were estimated by logistic regression at a confidence level of 95%.
Forty percent of the cases with FS had iron-deficiency anemia, compared to 26% of children with febrile illness without seizure and 12% of healthy children. The Odds ratio for iron-deficiency anemia in the patients with FS was 1.89 (95% CI, 1.04-5.17) compared to the febrile children without convulsion and 2.21 (95% CI, 1.54-3.46) compared to the healthy group.
Children with FS are more likely to be iron-deficient than those with febrile illness alone and healthy children. Thus, iron-deficiency anemia could be a risk factor for FS.
鉴于热性惊厥的复发情况及家庭成本，许多研究试图确定其风险因素。近期一些研究报告称，热性惊厥患儿中贫血更为常见，而另一些研究则报告缺铁会提高惊厥阈值。本研究旨在比较首次发生热性惊厥的儿童、仅患有发热性疾病的儿童以及健康儿童中的缺铁性贫血情况。
本病例对照研究在2009年9月至2010年9月期间，对霍拉马巴德马丹尼医院的三组儿童（首次热性惊厥组、发热无惊厥组和健康组）进行了评估，共300名儿童。入院时采用鼓膜法测量体温。对所有参与者进行了血常规分类、平均红细胞体积（MCV）、平均红细胞血红蛋白含量（MCH）、平均红细胞血红蛋白浓度（MCHC）、血清铁、血浆铁蛋白和总铁结合力（TIBC）检测。数据通过频率、均值、标准差、方差分析和卡方统计检验进行分析。通过逻辑回归在95%置信水平下估计比值比。
热性惊厥患儿中有40%患有缺铁性贫血，相比之下，发热无惊厥儿童中有26%，健康儿童中有12%。与发热无惊厥儿童相比，热性惊厥患者缺铁性贫血的比值比为1.89（95%置信区间，1.04 - 5.17），与健康组相比为2.21（95%置信区间，1.54 - 3.46）。
热性惊厥患儿比仅患有发热性疾病的儿童和健康儿童更易缺铁。因此，缺铁性贫血可能是热性惊厥的一个风险因素。
