Mashhadi Mohammad Ali, Shakiba Mansoor, Zakeri Zahra
Genetics of Non-Communicable Disease Research Center, Zahedan University of Medical Sciences, Zahedan, Iran.
Dept. of Psychiatry, Zahedan University of Medical Sciences, Zahedan, Iran.
Iran J Cancer Prev. 2013 Winter;6(1):12-6.
The symptoms related to depression in patients with cancer are amajor problem and could influence the treatment and survival of patients. This disorder is varied in different populations and in different studies.
We evaluated the prevalence of depression with Beck Depression Inventory (BDI) scale in 400 patients with cancer. This measurement was after the diagnosis of malignancy and before chemotherapy or radiotherapy.
The mean age of patients was 45 ±8.5 years, and female to male ratio was 45/55. The prevalence of depression was 24.8 % and 28% in males and females. All patients with depression had mild to moderate depression. Prevalence of depression was significantly higher in younger cases (P<0.0001). According to the site of malignancy, prevalence of depression was significantly highest in patients with breast cancer, following metastatic of unknown origin and gastrointestinal cancer and the lowest prevalence was observed in patients with hematologic malignancy (p <0.0001). Also, we observed a significant higherprevalence of depression in single versus married patients (p <0.0001), in patients with higher education (p <0.0001) and patients who had knowledge about their disease in comparison with those who had no knowledge (p <0.0001).
The prevalence of depression and its severity in cancer patients in South east of Iran was lower than other studies and it seems that this situation may be related to high religious beliefs in this region, high prevalence of illiteracy and lack of knowledge about their underlying disease.
癌症患者中与抑郁相关的症状是一个主要问题，可能会影响患者的治疗和生存。这种疾病在不同人群和不同研究中有所不同。
我们使用贝克抑郁量表（BDI）对400名癌症患者的抑郁患病率进行了评估。该测量在恶性肿瘤诊断后、化疗或放疗前进行。
患者的平均年龄为45±8.5岁，男女比例为45/55。男性和女性的抑郁患病率分别为24.8%和28%。所有抑郁患者均为轻度至中度抑郁。年轻患者的抑郁患病率显著更高（P<0.0001）。根据恶性肿瘤的部位，乳腺癌患者的抑郁患病率显著最高，其次是不明来源转移癌和胃肠道癌患者，血液系统恶性肿瘤患者的患病率最低（p<0.0001）。此外，我们观察到单身患者与已婚患者相比抑郁患病率显著更高（p<0.0001），受过高等教育的患者（p<0.0001）以及了解自己疾病的患者与不了解疾病的患者相比抑郁患病率显著更高（p<0.0001）。
伊朗东南部癌症患者的抑郁患病率及其严重程度低于其他研究，这种情况似乎可能与该地区较高的宗教信仰、高文盲率以及对其潜在疾病缺乏了解有关。
